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Name: |
Li Qi
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Education: |
Ph.D
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Positions: |
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Academic title: |
Principal Investigator
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Phone: |
021-68077849
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Fax: |
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E-mail: |
Qi.li@simm.ac.cn
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Personal Website: |
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Postal Code: |
201203
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Mailing Address: |
555 Zuchongzhi Road, zhangjiang Hiptech Park, Pudong, Shanghai
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| Resume: |
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Qi Li, Ph.D., Principal Investigator of Shanghai Institute of Materia Medica, Chinese Academy of Sciences. Dr. Li received his Ph.D. from Institute of Organic Chemistry, Chinese Academy of Sciences under the supervision of Prof. Yian Shi in 2013. From Aug 2013 through Nov 2020, he worked at Tsinghua University as a postdoctoral researcher and University of California, San Francisco as postdoctoral researcher/associate specialist. Since Nov 2020, Dr. Li has joined in Shanghai Institute of Materia Medica, Chinese Academy of Sciences. His research interests mainly focus on discovering new generation antibiotics to overcome multidrug resistant pathogens.
Education:
2009.09 - 2013.07 Ph.D., Organic Chemistry Institute of Chemistry, the Chinese Academy of Sciences
2006.09 - 2009.07 M.S., Medicinal Chemistry Shenyang Pharmaceutical University
2000.09 - 2004.07 B.S., Medicinal Chemistry Shenyang Pharmaceutical University
Professional Experience:
2020.11-Present Professor, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
2016.01-2020.11 Postdoc/Associate specialist, University of California, San Francisco
2013.08-2016.01 Postdoc Tsinghua University
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| Research Directions |
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Total synthesis, modification and target confirmation of bioactive natural products
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| Awards & Honors |
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1.General Financial Grant (2014M5609500), China Postdoctoral Science Foundation, 2014
2.Postdoctoral fellowship, Center for Life Science, Beijing, China, 2013
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| Achievements |
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1.设计并完成了一条模式化，汇聚式和可以大量制备的A组分streptogramin抗生素的全合成路线。在这条路线中，将天然产物拆分成化学结构复杂程度相似的左右两个部分，而这两个部分可以由7个简单合成砌块经过3-5步化学合成得到；最终，四个streptogramin A抗生素可以经过6-8线性步骤制备，为新一代streptogramin A抗生素的发现奠定了坚实的基础（J. Am. Chem. Soc., 2017）。
2.为了克服多重耐药性和streptogramin A的天然耐药机制（Vat耐药机制），以上述合成路线为蓝本，建立了一个新一代streptogramin A抗生素发现平台。通过这一平台设计合成了超过100个streptogramin A类似物，其中的一个化合物在体外对多重耐药菌的抑制能力上都优于flopristin（成功通过二期临床试验）。同时，在VatA耐药基因高表达金黄色葡萄糖球菌感染的小鼠模型体内实验中也表现出优良的抑制能力，并且优于临床候选药物flopristin。这项研究缓解了VatA介导的耐药性又同时表现出优异的抗生素活性，为发现新一代streptogramin A抗生素打开了大门。第二这项研究成果惊人的展示了前沿模块化合成有机化学在推动明天的制药科学方面仍未开发的巨大潜力。第三，从更广泛的意义上讲，这项研究成果会使人们更大胆，并更加积极地追求富含Csp3 /大环的小分子作为独特的有效化学物质，以驱动前沿药物的发现和化学生物学（Nature, 2020）。
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| Grants & Research Projects |
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| Pubilcations |
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1.Li, Q.; Seiple, I. B. Modular synthesis of streptogramin antibiotics. Synlett 2020, in press.
2.Li, Q.*; Pellegrino, J.*; Lee, D. J.; Tran, A. T.; Chaires, H. A.; Wang, R.; Park, J. E.; Ji, K.; Chow, D.; Zhang, N.; Brilot, A. F.; Biel, J. T.; van Zundert, G.; Borrelli, K.; Shinabarger, D.; Wolfe, C.; Murray, B.; Jacobson, M. P.; Mühle, E.; Cheaneau, O.; Fraser, J. S.; Seiple, I. B. Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature 2020, 586, 145-150. (*equal contribution).
3.Shi, X.*; Li, Q.*; Dai, Z.; Tran, A.; Feng, S.; Ramirez, A. S.; Lin, Z.; Wang, X.; Chow, T. T.; Seiple, I. B.; Huang, B. Label-retention expansion microscopy. (*equal contribution). [BioRxiv].
4.Li, Q.; Seiple, I. B. A Concise Route to Virginiamycin M2. Tetrahedron 2019, 75, 3309-3318. (Special issue in honor of Prof. Ryan Shenvi’s Tetrahedron Young Investigator Award).
5.Seiple, I. B.; Li, Q. Method of Making Streptogramin Compositions and the Use Thereof. PCT/US2018/044708.
6.Hu, L.*; Li, Q.*; Yao, L.？; Xu, B.; Wang, X.; Liao, X. Enantioselective and Divergent Syntheses of Alstoscholarisine A, E and their Enantimers. Org. Lett. 2018, 20, 6202-6205. (*equal contribution).
7.Li, Q.; Seiple, I. B. Modular, Scalable Synthesis of Group A Streptogramin Antibiotics. J. Am. Chem. Soc. 2017, 139, 13304-13307.
8.Li, Q.; Xia, T.; Yao, L.; Deng, H.; Liao, X. Enantioselective and Diastereoselective Azo-coupling/Iminium-Cyclization: A Unified Strategy for the Total Synthesis of (-)-Psychotriasine and (+)-Pestalazine B. Chem. Sci. 2015, 6, 3599-3605.
9.Li, Q.; Li, G.; Ma, S.; Feng, P.; Shi, Y. An Approach to the Skeleton of Aspidophylline A. Org. Lett. 2013, 15, 2601-2603.
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