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Faculty and Staff
Faculty and Staff
TAN Minjia

Ph.D,Principal Investigator Chemical Biology Research Center;Chemical Proteomics Center (CPC)
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Mailing Address:
555 Zu Chong Zhi Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai, P.R.China

Dr. Tan’s current research interest is focused on the development of new mass spectrometry-based proteomics technologies to characterize the roles of protein post-translational modifications (PTMs) in cellular physiology and diseases, discover new biomarkers, and explore new therapeutic approaches. 


09/1999-06/2003, B.Sc. degree in Pharmacy, Fudan University 

09/2003-07/2008, Ph.D. degree in Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences 


10/2008-08/2012 Postdoctoral Scholar, Ben May Department for Cancer Research, the University of Chicago 

09/2012-present, Professor, Shanghai Institute of Materia Medica, Chinese Academy of Sciences 

Research Directions
Developing new mass spectrometry-based proteomics technologies to characterize the roles of protein post-translational modifications (PTMs) in cellular physiology and diseases, discover new biomarkers, and explore new therapeutic approaches.

Social Titles

Awards & Honors

2019, VCANBIO Award for Innovations and Breakthroughs in Life Sciences and Medicine 

2013, Young Investigator Award of China Human Proteome Organization (CNHUPO) 


Grants & Research Projects
1.  973, Ministry ofScience and Technology (MOST), China, The Draft of Chinese HumanProteome / The protein expression proteomeof human respiratory system,  Project Leader,  2014.2-2018.8
2.  Natural Science Foundation of China, Systems analysis and functional studies of regulatory networks of protein lysine succinylation pathway , Project Leader,  2014.01-2017.12
3.  Shanghai science and Technology Committee, Proteomics analysis ofdynamic changes of protein Succinylationin evolution, Project Leader,  2013.10-2015.9
4.  National Science and Technology Major Project of the Ministry of Science and Technology of China , Key technologies ofMolecularly targetedanticancer drugs biomarker and novel detection kit, Co-investigator, 2012.01-2015.12

Selected Publications

1.Liu Z, Liu Y, Qian L, Jiang S, Gai X, Ye S, Chen Y, Wang X, Zhai L, Xu J, Pu C, Li J, He F, Huang M*, and Tan M*. A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies. Mol Cell, 2021, 81: 4076-4090  

2.Li Y, Xu J, Lu Y, Bian H, Yang L, Wu H, Zhang X, Zhang B, Xiong M, Chang Y, Tang J, Yang F, Zhao L, Li J, Gao X, Xia M*, Tan M*, Li J*. DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing. Cell Metab. 2021 33: 2004–2020.  

3.Liu P, Cong X, Liao S, Jia X, Wang X, Dai W, Zhai L, Zhao L, Ji J, Ni D, Liu Z, Chen Y, Pan L, Liu W, Zhang J, Huang M, Liu B*, Tan M*. Global identification of phospho-dependent SCF substrates reveals a FBXO22 phosphodegron and an ERK-FBXO22-BAG3 axis in tumorigenesis. Cell Death Differ, 2021 DOI: 10.1038/s41418-021-00827-7  

4.Xu J, Zhang C, Wang X, Zhai L, Ma Y, Mao Y, Qian K, Sun C, Liu Z, Jiang S, Wang M, Feng L, Zhao L, Liu P, Wang B, Zhao X, Xie H, Yang X, Zhao L, Chang Y, Jia J, Wang X, Zhang Y, Wang Y, Yang Y, Wu Z, Yang L, Liu B, Zhao T, Ren S, Sun A, Zhao Y, Ying W, Wang F, Wang G, Zhang Y, Cheng S, Qin J, Qian X, Wang Y*, Li J*, He F*, Xiao T*, Tan M*. Integrative proteomic characterization of human lung adenocarcinoma. 2020 Cell 182: 245-261 

5.Huang X, Yan J, Zhang M, Wang Y, Chen Y, Fu X, Wei R, Zheng XL, Liu Z, Zhang X, Yang H, Hao B, Shen Y, Su Y, Cong X, Huang M, Tan M*, Ding J*, Geng M*. Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors. Cell 2018,175:186-199.  

6.Liu B, Jiang S, Li M, Xiong X, Zhu M, Li D, Zhao L, Qian L, Zhai L, Li J, Lu H, Sun S, Lin J, Lu Y *, Li X*, Tan M*. Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis. Nat Commun 2018, 9: 4770  

7.Hu H, Zhao W, Zhu M, Zhao L, Zhai L, Xu JY, Liu P, Tan M*. LysargiNase and Chemical Derivatization Based Strategy for Facilitating In-Depth Profiling of C-Terminome. Anal Chem. 2019 91: 14522-14529 

8.Tan M.#, Peng  C.#, Anderson K.A.#, Chhoy P., Xie Z., Dai L., Park J.S., Chen Y., Huang H., Zhang Y., Ro J., Wagner G.R., Green M.F., Madsen A.S., Schmiesing J., Peterson B.S., Xu G., Ilkayeva O.R., Muehlbauer M.J., Braulke T., Mühlhausen C., Backos D.S., Olsen C.A., McGuire P.J., Pletcher S.D., Lombard D.B., Hirschey M.D.*, Zhao Y*. Lysine Glutarylation Is a Protein Post-Translational Modification Regulated by SIRT5. Cell Metab 2014,19: 605-617 

9.Tan M.#, Luo H.#, Lee S.#, Jin F., Yang J.S., Montellier E., Buchou T., Cheng Z., Rousseaux S., Rajagopal N., Lu Z., Ye Z., Zhu Q., Wysocka J., Ye Y., Khochbin S., Ren B., Zhao Y*. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell 2011, 146, 1016-1028 

10.Zhang Z.#, Tan M.#, Xie Z., Dai L., Chen Y., Zhao Y.*. Identification of lysine succinylation as a new post-translational modification. Nat Chem Biol 2011, 7, 58-63