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	Faculty and Staff

Name:	Zhang Jiwen	Education:	Ph.D
Positions:	Principal Investigator	Academic title:	Professor
Phone:	021-20231980	Fax:	021-20231980
E-mail:	jwzhang@simm.ac.cn	Personal Website:
Postal Code:	201203	Mailing Address:	501 Haike Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai, P.R.China.

Resume:

Prof. Dr. Jiwen Zhang, now serves as the principal investigator in Shanghai institute of Materia Medica (SIMM), Chinese Academy of Science. He has carried out the interdisciplinary research by establishing cooperation with research team at home and abroad. Aiming at the evaluation of DDS, he has established the pharmacokinetics theory for the sustained and controlled-release systems, putting forward the quantitative method for optimizing the formulation of the sustained and controlled-release systems, and has designed new formulation such as biomimetic DDS. Pointing at the complexity of the structure of pharmaceutical dosage forms, his team utilized primarily the synchrotron radiation light facility to establish quantitative methods for characterizing the irregular and dynamic structure of DDS. Novel cage-like tablet and the osmotic pump with new structures have been designed. His team has studied the release mechanisms associated with kinetic rate constants of supramolecular DDS by HPLC, SPR and SPRi as well as prediction by molecular simulation. He and his team are working on Structure Pharmaceutics for scales from molecule to dosage forms.

EDUCATION

1997-2001, School of Pharmacy, Shenyang Pharmaceutical University, Pharmaceutics, Ph.D.
1990–1993, School of Pharmacy, Chinese Pharmaceutical University, Pharmaceutics, M.S.
1986-1990, School of Pharmacy, Shenyang Pharmaceutical University, Pharmaceutical engineering, B.S.
1981-1984, Anqing Health School, Assistant Pharmacist

WORK EXPERIENCE

06/2007 – present, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Professor and Principal Investigator
01/2005 – 06/2014, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Vice director and director for the Department of Scientific Research, secretary of the academic committee, chairman of IACUC, director of the office for the major drug innovation project management, special assistant of the director-general of the institute
08/2003 – 01/2005, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, postdoctoral fellow
07/1995 – 08/2003, New Drug Research Institute in Anhui, director
06/1994 – 07/1995, Hangzhou Jiuyuan Gene Engineering Co., Ltd., Manager for Manufacturing Department
07/1993 – 06/1994, Luoyang Pharmaceutical Factory, Assistant of the chief Engineer
06/1984 – 09/1986, Anhui Provincial TB Institute, Assistant Pharmacist

Research Directions

Structure Pharmaceutics;
Pharmacokinetics for controlled/sustained drug delivery systems;
Supramolecular drug delivery systems.

Social Titles

Editor Member of the journals: International Journal of Pharmaceutics, Acta
Pharmaceutica Sinica B, and Asian Journal of Pharmaceutics
Member of the UK-China Advanced Material Research Institute
Member of the International Member of the Advisory Board for Science Bridges China

Awards & Honors

2012 Second Prize of Traditional Chinese Medicine of Zhejiang Province Scientific and Technological Award, Release / dissolution kinetics evaluation and software of traditional Chinese medicine formulations

Achievements

1. Pharmacokinetic theory of controlled release systems
We have systematically investigated the pharmacokinetic theory of the controlled/sustained release systems, and published a monograph titled as pharmacokinetics of controlled/sustained release systems (Science Press, May, 2009), which is a multidisciplinary work of pharmacokinetics and DDS as the first monograph in this field, providing theory and methodology for the quantitative design of in vitro release characteristics of DDS and in vivo pharmacokinetic evaluation.

2. Structures Pharmaceutics
Characterization methods for conventional dosage forms are mostly qualitative assessment. In our work, the synchrotron radiation facility met with the evaluation of DDS in view of the 3D and fractal dimension quantitative analysis for structure of formulations on the sub-micron and micron level. These works quantitatively correlated the release characteristics of formulations with its complex structures. Four levels of structures of formulations, namely, structure of molecules, structure of molecular assemblies, structure of particles and crystals, structure of dosage forms, were defined with 3D release theories and methods for design and optimization of DDS.

3. Study on supramolecular systems and drug release mechanism
Supramolecular systems based on cyclodextrins were studied for mechanism of the drug release kinetics. Supramolecular drug delivery technology and evaluation method of unstable drugs, e.g., artemisinins, were developed. The new concept of “kinetic studies for drug-receptor interactions” has been employed to research supramolecular systems. Molecular modeling prediction and methods like HPLC, SPR, SPRi are modified to determine koff of Supramolecular systems.

4. Research on novel drug delivery systems
Based on structural innovation, new types of tablets, e.g., dynamic structural osmotic pump tablets driven by liquid droplets formed spontaneously in situ in semi-solid matrix and tablets with cage-like structures, have been designed. New production process of tableting freeze-dried rapidly disintegrating tablets under low temperature was innovated. The team is also working on oral DDS of protein/peptide, injectable micelles for poorly water-soluble drugs and taste masking on bitter drugs for pediatric usages.

Grants & Research Projects

1.National Natural Science Foundation of China,Nano pharmacokinetics of bridging the cells and overall,2015.1-2019.12
2.National Natural Science Foundation of China,Three-dimensional drug release mechanism of controlled release formulations for insoluble drug, 2013.1-2016.12
3.International Cooperation Projects of Science and Technology Ministry,Improve the bioavailability and reduce malaria drug resistance of artemisinin-based drugs through drug combination,2009.1-2011.12

Pubilcations

(2013.1.1-)

[1] Xian-Zhen Yin, Ti-Qiao Xiao, Ashwini Nangia, Shuo Yang, Xiao-Long Lu, Hai-Yan Li, Qun Shao, You He, Peter York & Ji-Wen Zhang. In situ 3D topographic and shape analysis by synchrotron radiation X-ray microtomography for crystal form identification in polymorphic mixtures, Scientific Reports, 2016 Apr 21; 6: 24763.

[2] Tao Guo, Haiyan Li, Li Wu, Zhen Guo, Xianzhen Yin, Caifen Wang, Lixin Sun, Qun Shao, Jingkai Gu, Peter York, and Jiwen Zhang. Prediction of Rate Constant for Supramolecular Systems with Multiconfigurations. J. Phys. Chem. A, 2016, 120 (7), pp 981–991.

[3] Xian-Zhen Yin, Li Wu, Ying Li, Tao Guo, Hai-Yan Li, Ti-Qiao Xiao, Peter York, Ashwini Nangia, Shuang-Ying Gui & Ji-Wen Zhang. Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting. Scientific Reports, 2016, Feb 25; 6: 21770.

[4] Li Wu, Xianzhen Yin, Zhen Guo, Yajun Tong, Jing Feng, Peter York, Tiqiao Xiao, Min Chen, Jingkai Gu, Jiwen Zhang. Hydration induced material transfer in membranes of osmotic pump tablets measured by synchrotron radiation based FTIR. European Journal of Pharmaceutical Sciences, 2016,84:132–138.

[5] Caifen Wang, Xiaobo Wang, Xiaonan Xu, Botao Liu, Xu Xu, Lixin Sun, Haiyan Li, Jiwen Zhang. Simultaneous high-throughput determination of interaction kinetics for drugs and cyclodextrins by high performance affinity chromatography with mass spectrometry detection. Analytica Chimica Acta, 2016, 909:75-83.

[6] Zhen Guo, Xianzhen Yin, Congbiao Liu, Li Wu, Weifeng Zhu, Qun Shao, Peter York, Laurence Patterson, Jiwen Zhang. Microstructural investigation using synchrotron radiation X-ray microtomography reveals taste-masking mechanism of acetaminophen microspheres. Int J Pharmaceut, 2016,499, 47-57.

[7] Liandi Chi, Delin Wu, Zhuo Li, Minmin Zhang, Hongchun Liu, Caifen Wang, Shuangying Gui, Meiyu Geng, Haiyan Li, and Jiwen Zhang. Modified Release and Improved Stability of Unstable BCS II Drug by Using Cyclodextrin Complex as Carrier To Remotely Load Drug into Niosomes, Mol. Pharmaceutics, 2016, 13 (1), pp 113–124.

[8] X. Ren, C. Wang, L. Wu, H. Li, L. Chi, L. Sun, B.Wang, H. Cui, L. Angiolini, A. Bianchi, P. Caccia, S. Xing, X. Fu, J. Zhang. Bioactivity assay of porcine relaxin based on cAMP accumulation in THP-1 cells quantified by LC-MS/MS, Journal of Pharmaceutical and Biomedical Analysis, 2015; 111:320-3.

[9] Manli Wang, Xiaolong Lu, Xianzhen Yin, Yajun Tong, Weiwei Peng, Li Wu, Haiyan Li, Yan Yang, Jingkai Gu, Tiqiao Xiao, Min Chen, Jiwen Zhang. Synchrotron radiation-based Fourier-transform infrared spectromicroscopy for characterization of the protein/peptide distribution in single microspheres. Acta Pharmaceutica Sinica B, 2015, 5(3):270–276.

[10] Chi L, Liu R, Guo T, Wang M, Liao Z, Wu L, Li H, Wu D, Zhang J. Dramatic improvement of the solubility of pseudolaric acid B by cyclodextrin complexation: Preparation, characterization and validation. Int J Pharm, 2015, 479(2):349-356.

[11] Wang C, Ge J, Zhang J, Guo T, Chi L, He Z, Xu X, York P, Sun L, Li H. Multianalyte determination of the kinetic rate constants of drug-cyclodextrin supermolecules by high performance affinity chromatography. J Chromatogr A, 2014, 1359: 287-295.

[12] Xue Li, Haiyan Li, Qun Xiao, Liuyi Wang, Manli Wang, Xiaolong Lu, Peter York, Senlin Shi, Jiwen Zhang. Two-way effects of surfactants on Pickering emulsions stabilized by the self-assembled microcrystals of α-cyclodextrin and oil. Physical Chemistry Chemical Physics, 2014;16(27) :14059-69.

[13] Shuo Yang, Xianzhen Yin, Caifen Wang, Haiyan Li, You He, Tiqiao Xiao, Lixin Sun, Jiasheng, Peter York, Jun He, Jiwen Zhang. Release behaviour of single pellets and internal fine 3D structural features co-define the in vitro drug release profile of Tamsulosin sustained release capsules. AAPS J, 2014, 16(4): 860-871.

[14] Ying Li, Liuyi Wang, Li Wu, Xueju Zhang, Xue Li, Zhen Guo, Haiyan Li, Peter York, Shuangying Gui, Jiwen Zhang. Bio-mimetic drug delivery systems designed to help the senior population reconstruct melatonin plasma profiles similar to those of the healthy younger population. Acta Pharmaceutica Sinica B, 2014, 4: 60-66.

[15] Xianzhen Yin, Haiyan Li, Zhen Guo, Li Wu, Fangwei Chen, Marcel de Matas, Qun Shao, Tiqiao Xiao, Peter York, You He, Jiwen Zhang. Quantification of the relative importance of swelling and erosion in the controlled release of poorly water-soluble drugs using statistical modelling and synchrotron radiation X-ray computed microtomography. AAPS J, 2013, 15(4):1025-34.

[16] Xianzhen Yin, Haiyan LI, Ruihao Liu, Jing Chen, Junqiu Ji, Jun Chen, Qun Shao, Tiqiao Xiao, Peter York, You He, Jiwen Zhang. Fractal structure determines controlled release kinetics of monolithic osmotic pump tablets. J Pharm Pharmacol, 2013, 65 (7): 953-959.

[17] Ruihao Liu, Xianzhen Yin, Haiyan Li, Qun Shao Peter York, You He, Tiqiao Xiao, Jiwen Zhang. Visualization and quantitative profiling of mixing and segregation of granules using synchrotron radiation X-ray microtomography and three dimensional reconstruction. Int J Pharm, 2013, 445(1-2):125-133.

[18] Haiyan Li, Jingwen Ge, Tao Guo, Shuo Yang, Zhonggui He, Peter York, Lixin Sun, Xu Xu, Jiwen Zhang. Determination of the kinetic rate constant of cyclodextrin supramolecular systems by high performance affinity chromatography. J Chromatogr A, 2013, 1305:139-148.

[19] Dan Wang, Haiyan Li, Jingkai Gu, Tao Guo, Shuo Yang, Zhen Guo, Xueju Zhang, Weifeng Zhu, Jiwen Zhang. Ternary system of dihydroartemisinin with hydroxypropyl-β-cyclodextrin and lecithin: simultaneous enhancement of drug solubility and stability in aqueous solutions. J Pharmaceut Biome, 2013, 83: 141-148.

[20] Shahzeb Khan, Marcel de Matas, Jiwen Zhang, and Jamshed Anwar. Nanocrystal Preparation: Low-Energy Precipitation Method Revisited. Cryst Growth Des, 2013, 13(7): 2766-2777.

[21] Quanlei Zhu, Tao Guo, Dengning Xia, Xiuying Li, Chunliu Zhu, Haiyan Li, Defang Ouyang, Jiwen Zhang and Yong Gan. Pluronic F127-modified liposome-containing tacrolimus–cyclodextrin inclusion complexes: improved solubility, cellular uptake and intestinal penetration. J Pharm Pharmacol, 2013, 65(8): 1107-1117.