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Name: |
Gan Yong
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Education: |
Ph.D
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Positions: |
Professor/Ph.D candidate supervisor, Principal Investigator
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Academic title: |
Professor
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Phone: |
021-20231975
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Fax: |
021-20231975
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E-mail: |
ygan@simm.ac.cn
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Personal Website: |
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Postal Code: |
201203
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Mailing Address: |
501 Haike Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai, P.R.China. 201203
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| Resume: |
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Prof. Yong Gan now serves as the principal investigator of the Centre for Drug Delivery Research in Shanghai institute of Materia Medica (SIMM), Chinese Academy of Science. His major interests focus on physical pharmacy. Specifically, he has designed novel drug delivery systems with further exploration of the underlying mechanisms overcoming the key physiological barriers. He has now published more than 70 peer-reviewed papers in international journals, including Science Advances, Nature Communications, PNAS, ACS Nano, Nano Letters, Advanced Functional Materials, Biomaterials, Journal of Controlled Release. He has also participated in writing and editing 4 books. In the aspect of translational medicine, Prof. Gan has rationally designed a series of innovative preparations with good druggability, some of which are now undergoing clinical trials. Up to now, he holds 35 authorized patents, 15 clinical approvals for new drugs, and 4 commercial formulations.
Education Experience
1997.09 - 2002.06 Shenyang Pharmaceutical University, School of Pharmacy, Pharmaceutics, Ph.D.
1993.09 - 1997.06 Shenyang Pharmaceutical University, School of Pharmacy, Pharmacy Analysis, B.S.
Working Experience
2008.10 - Present Shanghai Institute of Materia Medica, Center for Drug Delivery, Professor
2004.10 - 2008.10 Shanghai Institute of Materia Medica, Center for Drug Delivery, Associate Professor
2002.07 - 2004.07 Shanghai Institute of Materia Medica, Postdoctoral Fellow
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| Research Directions |
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1. Research on physical pharmacy.
2. Novel drug carriers design and research on the mechanism of overcoming the key physiological barriers.
3. Translational research on the innovative drug preparations.
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| Social Titles |
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The Pharmaceutics Committee of Chinese Pharmaceutical Association, Senior Member
The Second Council of China Particle Society, Young Council
The Nanomedicine and Engineering Committee of Chinese Biomedical Engineering Society, Member
Editor of the journal “Asian Journal of Pharmaceutical Sciences”, “Acta Pharmaceutica Sinica B” and “Chinese Journal of Pharmaceuticals”, etc.
Center for Drug Evaluation (NMPA), External Experts
Academic Committee of NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients, Member
Expert Committee of National Engineering Research Center Modernization of Extraction and Separation Process of TCM, Member
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| Awards & Honors |
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2019, the 4th China Pharmaceutical Association - Yiling biomedical Youth Award, China Pharmaceutical Association.
2019, Young and Middle-aged Leading Talents in Science and Technology Innovation of Promotion Plan, Ministry of science and technology.
2017, Wang Kuancheng First talent plan Award, Personnel Bureau of Chinese Academy of Sciences.
2017, Special Researcher of Chinese Academy of Sciences, Personnel Bureau of Chinese Academy of Sciences.
2010, China Pharmaceutical Association - Youth pharmacy award of Shiyao group, China Pharmaceutical Association.
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| Achievements |
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1. In the view of physical pharmacy, Prof. Gan has designed novel drug delivery systems with further exploration of the underlying mechanisms overcoming the key physiological barriers. He has revealed the several rules of physical properties, such as shape and rigidity, in determining the delivery efficiency of drug carriers. Meanwhile, he has described the unique rotation-hopping diffusion pattern of rod-shaped carriers and the rod-like microcosmic motion of the semi-elastic carriers, both of which are the mechanisms of their efficient transportation.
2. In the field of translational medicine, he has focused on the development of innovative oral preparations and novel lipid-based injections. Based on proprietary technology, Glipizide Controlled Release Tablets have been approved to be listed. Glumetinib tablet (a first class anticancer drug) and huperzine A controlled-release tablet (an anti-alzheimer’s drug), developed based on absorption and slow release technologies, also have been approved for clinical trial. In addition, the fish oil nanoemulsion injection with anti-inflammatory effect has been manufactured on a large-scale.
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| Grants & Research Projects |
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Scientific research projects undertaken：
1．The Major International Joint Reaearch Project of Chinese Academy of Sciences, Research on efficient intracellular delivery of nanodrug carriers, Project principal, 2020.01-2022.12
2．The Shanghai Science and Technology Committee, The rational shape design of high-efficiency nano-drug carrier and the research on the microscopic movement mechanism to overcome the physiological barrier, Project principal, 2018.11-2020.10
3．National Natural Science Foundation, Research on the influence of nanoparticle shape on the efficiency of oral delivery and the microscopic mechanism to overcome the absorption barrier, Project principal, 2018.01-2021.12
4．The Strategic Priority Research Program of Chinese Academy of Sciences, Research on the preparation technology of drug microcapsules on space microfluidic chip, Project principal, 2018.01-2020.12
5．The Shanghai Science and Technology Committee, The rational shape design of high-efficiency nano-drug carrier and the research on the microscopic movement mechanism to overcome the physiological barrier, Project principal, 2018.10-2020.09
6．The Shanghai Science and Technology Committee, Research on the effect of high bioavailability on the efficiency of drug delivery to overcome the microscopic movement mechanism of absorption barrier, Project principal, 2017.10-2019.09
7．Chinese Academy of Sciences, Wang Kuancheng Leading industry research talent support project, Project principal, 2017.01-2019.12
8．National Natural Science Foundation of China, Design of intelligent polypeptide nano-carriers based on pathological microenvironment of intestinal epithelial cells in diabetes mellitus and research on the mechanism of intercellular transport, Project principal, 2016.01-2019.12
9．CAS-NovoNordisk Research Foundation, A particle engineering approach to improve the tabletability of poorly compressible absorption enhancers in an oral peptide formulation, Project principal, 2016.01-2017.12
10．National Natural Science Foundation of China, Based on the design of substrate prodrug of BL side transporter of epithelial cells and the research on the mechanism of intelligent nano-carrier of prodrug to promote oral absorption, Project principal, 2014.01-2017.12
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| Pubilcations |
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1.Aohua Wang#, Weiwei Fan#, Tiantian Yang, Shufang He, Yiwei Yang, Miaorong Yu, Li Fan, Quanlei Zhu, Shiyan Guo, Chunliu Zhu, Yong Gan*. Liver-target and glucose-responsive polymersomes toward mimicking endogenous insulin secretion with improved hepatic glucose utilization. Advanced Functional Materials. 2020, 30(13):1910168.
2.Di Nie#, Zhuo Dai#, Jialin Li#, Yiwei Yang, Ziyue Xi, Jie Wang, Wei Zhang, Kun Qian, Shiyan Guo, Chunliu Zhu, Rui Wang, Yiming Li, Miaorong Yu, Xinxin Zhang, Xinghua Shi, Yong Gan*. Cancer-cell-membrane-coated nanoparticles with a yolk-shell structure augment cancer chemotherapy. Nano Letters. 2020, 20(2):936-946.
3.Yiwei Yang#, Falin Tian#, Di Nie#, Yuan Liu, Kun Qian, Miaorong Yu, Aohua Wang, Yaqi Zhang, Xinghua Shi*, Yong Gan*. Rapid transport of germ-mimetic nanoparticles with dual conformational polyethylene glycol chains in biological tissues. Science Advances. 2020, 6(6):eaay9937.
4.Shiyan Guo, Di Sun, Dalong Ni, Miaorong Yu, Kun Qian, Wei Zhang, Yiwei Yang, Sha Song, Yang Li, Ziyue Xi, Jie Wang, Jingyi Li, Yan Wei, Kaixian Chen*, Yong Gan*, Zhengtao Wang*. Smart tumor microenvironment-responsive nanotheranostic agent for effective cancer therapy. Advanced Functional Materials. 2020.
5.Zhuo Dai#, Miaorong Yu#, Xin Yi*, Zeming Wu, Falin Tian, Yunqiu Miao, Wenyi Song, Shufang He, Ejaj Ahmad, Shiyan Guo, Chunliu Zhu, Xinxin Zhang, Yiming Li, Xinghua Shi, Rui Wang*, Yong Gan*. Chain-length- and saturation-tuned mechanics of fluid nanovesicles direct tumor delivery. ACS Nano. 2019, 13(7):7676-7689.
6.Miaorong Yu#, Wenyi Song#, Falin Tian#, Zhuo Dai, Quanlei Zhu, Ejaj Ahmad, Shiyan Guo, Chunliu Zhu, Haijun Zhong, Yongchun Yuan, Tao Zhang, Xin Yi, Xinghua Shi*, Yong Gan*, Huajian Gao*. Temperature- and rigidity-mediated rapid transport of lipid nanovesicles in hydrogels. Proceedings of the National Academy of Sciences of the United States of America. 2019, 116(12):5362-5369.
7.Weiwei Fan, Dengning Xia, Quanlei Zhu, Xiuying Li, Shufang He, Chunliu Zhu, Shiyan Guo, Lars Hovgaard, Mingshi Yang, Yong Gan*. Functional nanoparticles exploit the bile acid pathway to overcome multiple barriers of the intestinal epithelium for oral insulin delivery. Biomaterials. 2018, 151:13-23.
8.Miaorong Yu#, Lu Xu#, Falin Tian#, Qian Su, Nan Zheng, Yiwei Yang, Jiuling Wang, Aohua Wang, Chunliu Zhu, Shiyan Guo, Xinxin Zhang, Yong Gan*, Xinghua Shi*, Huajian Gao*. Rapid transport of deformation-tuned nanoparticles across biological hydrogels and cellular barriers. Nature Communications. 2018, 9(1):2607.
9.Shufang He, Weiwei Fan, Na Wu, Jingjing Zhu, Yunqiu Miao, Xiaran Miao, Feifei Li, Xinxin Zhang*, Yong Gan*. Lipid-based liquid crystalline nanoparticles facilitate cytosolic delivery of siRNA via structural transformation. Nano Letters. 2018, 18(4):2411-2419.
10.Miaorong Yu#, Jiuling Wang#, Yiwei Yang#, Chunliu Zhu, Qian Su, Shiyan Guo, Jiashu Sun, Yong Gan*, Xinghua Shi*, Huajian Gao*. Rotation-facilitated rapid transport of nanorods in mucosal tissues. Nano Letters. 2016, 16(11):7176-7182.
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