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Name:
Wu Beili
Education:
Ph.D

Positions:
Principal Investigator
Academic title:
Professor
Phone:
20239065
Fax:
20231966
E-mail:
beiliwu@mail.shcnc.ac.cn
Personal Website:
Postal Code:
201203
Mailing Address:
501 Hai Ke Road , Zhang Jiang Hi-Tech Park, Pudong, Shanghai, P.R.China
Resume:

1997.09-2001.07 Beijing Normal University B.S.

2001.07-2006.09 Tsinghua University Ph.D.

2007.04-2011.08 The Scripps Research Institute Postdoctoral. 2011.08-present Shanghai Institute of Materia Medica, Chinese Academy of Sciences. Professor.


Research Directions

Dr. Wu is mainly focused on structural studies of G protein-coupled receptors (GPCRs), including: 1. High resolution crystal structure determination of GPCRs; 2. Structure-function relations of GPCRs; 3 GPCR structure based drug discovery.


Social Titles

Awards & Honors

Achievements
 

Grants & Research Projects

Pubilcations
  1. Li P, Shu C, Wu B, Ding Y, Shen B and Rao Z. Crystallization and preliminary X-ray diffraction analysis of FKBP52 N-terminal domain. ActaCryst. D. 2002, 58:2168-2169
  2. Li P, Wang L, Ding Y, Wu B, Shu C, Nie A, Li S, Shen B and Rao Z. Crystallization and preliminary X-ray diffraction analysis of FKBP12 complexed with a novel neurotrophic ligand. Protein and Peptide Letters. 2002, 5:459-463
  3. Wu B, Li P, Shu C, Shen B and Rao Z. Crystallization and preliminary crystallographic studies on the C-terminal Domain of human FKBP52. ActaCryst. D. 2003, 59:2269-2271
  4. Li P, Ding Y, Wu B, Shu C, Shen B and Rao Z. Crystal Structure of the N-terminal domain of human FKBP52. ActaCryst. D. 2003, 59:16-22
  5. Li P, Zhu J, Wu B, Gao F, Tien P, Rao Z and Gao GF. Crystallization and preliminary X-ray diffraction analysis of post-fusion six-helix bundle core structure from Newcastle disease virus F protein. ActaCryst. D. 2003, 59:1296-1298
  6. Li P, Wang L, Wu B, Shu C, Nie A, Shen B, Li S and Rao Z. Crystallization and preliminary X-ray diffraction analysis of FKBP12 complexed with a new neurotrophic ligand. Progress in Natural Science. 2003, 13:765-767
  7. Wu B, Li P, Liu Y, Lou Z, Ding Y, Shu C, Ye S, Bartlam M, Shen B &Rao Z. 3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilinheterocomplex. Proc Natl Acad Sci USA. 2004, 101:8348-8353.
  8. Sun Y, Li X, Wu B, Sun P and Rao Z. Crystallization and Preliminary Crystallographic Analysis of Human eukaryotic translation initiation factor 5A (eIF-5A). Protein and Peptide Letters. 2005, 12:713-715
  9. Wu B, Liu Y, Zhao Q, Liao S, Zhang J, Bartlam M, Chen W &Rao Z. Crystal Structure of RS21-C6, involved in nucleoside triphosphate pyrophosphohydrolysis. Journal of Molecular Biology. 2007, 367 (5): 1405-12
  10. Zhao Q, Oin L, Jiang F, Wu B, Yue W, Xu F, Rong Z, Yuan H, Xie X, Gao Y, Bai C, Bartlam M, Pei X &Rao Z. Structure of human Spindlin1: Tandem TUDOR-like domains for cell cycle regulation. Journal of Biological Chemistry. 2007, 282(1): 647-656
  11. Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC, Hamel DJ, Kuhn P, Handel TM, Cherezov V & Stevens RC. Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science. 2010, 330: 1066-1071.