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Name:
Wu Beili
Education:
Ph.D

Positions:
Principal Investigator
Academic title:
Professor
Phone:
+86-021-20239065
Fax:
20231966
E-mail:
beiliwu@simm.ac.cn
Personal Website:
Postal Code:
201203
Mailing Address:
501 Hai Ke Road , Zhang Jiang Hi-Tech Park, Pudong, Shanghai, P.R.China
Resume:

WU Beili got her Ph. D. degree at Tsinghua University, Beijing in 2006, and worked as a postdoctoral fellow at The Scripps Research Institute in La Jolla, California from 2007 to 2011. She is currently a Professor at Shanghai Institute of MateriaMedica (SIMM), CAS. Dr. Wu has been focused on protein structural biology, studying protein structure and function relations by solving high-resolution protein crystal structures for over ten years. Her current research is focused on structural studies of G protein-coupled receptors (GPCRs), aiming to understand the molecular mechanisms of signal recognition and transduction by different GPCRs, and providing clues about next generation GPCRdrug discovery. She has established a GPCR structural biology research platform at SIMM, and is making great progress on structural studies of many key GPCRs.

EDUCATION
09/01/1997– 07/31/2001, Beijing Normal University, BA 

09/01/2001– 07/31/2006, Tsinghua University, Ph.D.

WORK EXPERIENCE

04/01/2007– 07/18/2011, The Scripps Research Institute, La Jolla, US , Post Doctor 

07/19/2011 till now, Shanghai Institute of MateriaMedica, CAS, Professor

12/01/2012 till now, ShanghaiTech University, Invited Professor


Research Directions
Prof. WU Beili's research is focused on structural biology studies of GPCRs by solving high-resolution crystal structures of different GPCRs to study structure-function relations of GPCRs and perform structure-based drug design and discovery. Her futureresearch directions include:
1. Structuredetermination of complexes between GPCRs and novel ligands
2. Structure determination of complexes between GPCRs and endogenous protein ligands
3. Structure determination of GPCRs withoutstructural information

Social Titles
Since 2012, Structural Biology and Molecular Biophysics Committee, Shanghai Society of Biophysics
Since 2014, Molecular Biophysics Committee, the Biophysical Society of China

Awards & Honors

09/2012,  Shanghai Pujiang Talent
05/2014,  2013 May 4th Medal in Shanghai Science and Technology System
06/2014,  Chinese Academy of Sciences Shanghai BranchYoung Scholar’s Award


Achievements

Prof. WU Beili started her research group at Shanghai Institute of MateriaMedica (SIMM), CAS in July 2011. Within two years, her group established a GPCR structural biology research platform, and successfully solved crystal structures of several GPCRs. The studies were published on Science and Nature. Her research achievements in the recent five years are in details as the following:

1. Structural studies of chemokine receptor CXCR4
 Complex structures of CXCR4 bound to small molecule antagonist IT1t and peptide ligand CVX15, respectively, were determined by Prof. Wu in 2010.The results was published on Science in November 2011 [Science, 2010, 330: 1066 (Beili Wu as the first author)]

2. Structural studies of chemokine receptor CCR5
After the structural determination of CXCR4, Dr. Wu continued her effort on structural studies of HIV-1 co-receptors by solving the complex structure of CCR5 bound to an anti-HIV drug maraviroc in 2013. The CCR5 structural study was published on Science in September 2013 [Science, 2013, 341:1387 (Beili Wu as the corresponding author)]

3. Structural studies of purinergic receptor P2Y12R
In 2013, Prof. Wu's group solved complex structures of human purinergic receptor P2Y12R bound to an antagonist and an agonistby collaborating with Dr. Qiang Zhao’s lab at SIMM. The P2Y12R structures were published as two research papers “back to back” on Nature in May 2014 [Nature, 2014, 509: 115-118 and Nature, 2014, 509: 119-122 (Beili Wu as one of the co-corresponding authors)].


Grants & Research Projects

1. Shanghai Institute of MateriaMedica and Chinese Academy of Sciences “Hundred Talents”,  Start-up Package,  Project Leader, 2011.7-2015.12
2. NIH,  R01 Molecular Mechanism of HIV Entry Mediated by Chemokine Receptor CCR5,  Project Leader,  2012.2-2017.1
3. 973, Ministry of Science and Technology(MOST), China,  Basic Research on GPCR Drug Targets Involved in Cardiovascular Diseases, Sub-project Leader, 2012.1-2016.12
4. 973, Ministry of Science and Technology(MOST), China,  Novel Technology and Method Research in Structural Biology Studies of Protein Complexes and Membrane Proteins, Participant, 2014.1-2018.12
5. National Science and Technology Major Project, Ministry ofScience and Technology(MOST), China, GPCR Structure and Function-based Drug Discovery, Participant, 2013.1-2015.12
6. National Science and Technology Major Project, Ministry ofScience and Technology(MOST), China, Key Technology Development and Platform Construction in GPCR Structure and Function-based Drug Discovery, Participant, 2012.1-2015.12
7.
Special Leading Science and Technology Project (type B), CAS,  Structure, Function and Regulation of Biological Marco-molecule Complexes, Core PI , 2014.1-2018.12   
8. Interactional Collaboration and Communication Project, National Natural Science Foundation of China, Protein Structure-based Anti-HIV Drug Discovery, Participant, 2012.1-2012.12   
9. Mianshang Project, National Natural Science Foundation of China, Crystal Structural Studies of Complexes between Chemokine Receptor CXCR4 and Peptide Ligands, Project Leader, 2013.1-2016.12   
10. Basic Research Project, Shanghai Science and Technology Commission, Structural Studies of Complexes between HIV-1 Co-receptor CXCR4 and Ligands, Project Leader, 2012.1-2014.12   
11. Pujiang Talent Program, Shanghai Science and Technology Commission, Structural Studies of G Protein-coupled Receptors, Project Leader, 2013.1-2014.12


Pubilcations

(2009.1.1至今) 

1.  Beili Wu, Ellen Y. T. Chien, Clifford D. Mol, Gustavo Fenalti, Wei Liu, VsevolodKatritch, Ruben Abagyan, Alexei Brooun, Peter Wells, F. Christopher Bi, Damon J. Hamel,
Peter Kuhn, Tracy M. Handel, VadimCherezov, Raymond C. Stevens*. Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science. 2010;330: 1066-1071.

2.  Qiang Zhao*, Beili Wu. Ice breaking in GPCR structural biology.ActaPharmacol Sin. 2012; 33(3): 324-334.

3.  Qiuxiang Tan, Ya Zhu, Jian Li, Zhuxi Chen, Gye Won Han, Irina Kufareva, Tingting Li, Limin Ma, Gustavo Fenalti, Jing Li, Wenru Zhang, XinXie, Huaiyu Yang, Hualiang Jiang, VadimCherezov, Hong Liu, Raymond C. Stevens, Qiang Zhao, Beili Wu*. Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. Science. 2013;341: 1387-1390.

4.  Lan Zhu, Qiang Zhao &Beili Wu*. Structure-based studies of chemokine receptors. CurrOpinStruct Biol. 2013; 23: 539-546.

5.  Jin Zhang, Kaihua Zhang, Zhan-GuoGao, Silvia Paoletta, Dandan Zhang, Gye Won Han, Tingting Li, Limin Ma,
Wenru Zhang, Christa E. Müller, Huaiyu Yang, Hualiang Jiang, VadimCherezov, VsevolodKatritch, Kenneth A. Jacobson, Raymond C. Stevens, Beili Wu* &Qiang Zhao*. Agonist-bound structure of the human P2Y12 receptor. Nature. 2014;509: 119-122.

6.  Kaihua Zhang, Jin Zhang, Zhan-GuoGao, Dandan Zhang, Lan Zhu, Gye Won Han, Steven M. Moss, Silvia Paoletta, EvgenyKiselev, Weizhen Lu, Gustavo Fenalti, Wenru Zhang, Christa E. Müller, Huaiyu Yang, Hualiang Jiang,
VadimCherezov, VsevolodKatritch, Kenneth A. Jacobson, Raymond C. Stevens, BeiliWu&Qiang Zhao*. Structure of the human P2Y12 receptor in complex with an antithrombotic drug. Nature. 2014;509: 115-118.