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Faculty and Staff
Faculty and Staff
Huang Yongzhuo

Principal Investigator;Professor/Ph.D candidate supervisor, Principal Investigator
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Mailing Address:
501 Hai Ke Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai, P.R.China

09/2002 - 07/2005 Zhejiang University, Ph.D.
09/1999 - 07/2002 Guangzhou University of Chinese TCM, M.S.
09/1995 - 07/1999 Guangzhou University of TCM, B.S.

07/2010 - present Shanghai Institute of Materia Medica, CAS
09/2008 - 06/2010 University of Michigan, Senior Research Fellow
11/2005 - 08/2008 University of Michigan, Research Fellow

Research Directions
1.Functional materials and drug delivery
3.Insoluble drug delivery technologies

Social Titles

1.2019–present Committee member of Pharmaceutics section, Chinese Pharmaceutical Society

2.2019–present Committee member of Nanomedicine section, Chinese Pharmaceutical Society

3.2012–present Committee member of Shanghai Pharmaceutical Society

4.2012–present Committee member of the World Federation of Chinese Medicine Societies.

5.2020-present Editorial Advisory Board member of Nano Letters

6.2020-present Editorial Board member of Journal of Controlled Release

7.2015–present Editorial board (Young member) Acta Pharmaceutica Sinica B

Awards & Honors

2011 Shanghai Pujiang Scholar Award, Shanghai

2013 Chinese Pharmaceutical Association-Sanoif Award for Young Investigators

2014 NSFC Excellent Young Investigator Award

2016 Young Peptide Scientist Award, CPS 2016

2017 Young leading scientists Award of the Ministry of Science and Technology, China

2019 NSFC Outstanding Young Investigator Award


1.We applied the cell-penetrating peptide-based nanotechology to overcome the tissue/cell biobarriers for enhanced anticancer drug delivery.

2.We applied cell-penetrating peptides and nanotechnology for mediating antigen percutaneous absorption. Such methods could be used for non-invasive transcutaneous immunization.


Grants & Research Projects

1.National Natural Science Foundation of China (NSFC), (91029743, PI) 2011.1–2013.12 "A prodrug-type probe system for cancer imaging"

2.National Natural Science Foundation of China (NSFC), (81172996, PI) 2012.1–2015.12 "Development of a novel bio-click chemistry for synthesis of prodrug-type protein toxin delivery system for cancer treatment"

3.National Basic Research Program of China (973 Program, 2013CB932503) 2013.1–2017.12 “Drug targeting delivery for treating primary brain tumor

4.National Natural Science Foundation of China (NSFC), (81373357, PI) 2014.1-2017.12 “Dual-targeting protein toxin drug delivery system for cancer therapy

5.National Basic Research Program of China (973 Program) (2014CB931202, PI) 2014.1-2018.12 “Self-adaptable nanosystems for gene delivery and its transfection mechanisms

6.National Natural Science Foundation of China (NSFC) (81422048, PI) 2015.1-2017.12 “Antibody-like structure design of a novel gene carriers for reversal TKI-resistance in lung cancer

7.National Natural Science Foundation of China (NSFC) (81673382, PI) 2017.1-2020.12 “Biomimetic delivery via albumin-hitching for tumor targeting delivery

8.National Natural Science Foundation of China (NSFC) (81521005, core member) 2016.1-2021.12 Science Fund for the Creative Research Groups (Pharmacuetics)


Recent selected publication (Since 2011):

1.Zhen ZN, Zhang JX, Jiang JZ, He Y, Zhang WY, Mo XP, Kang XJ, Xu Q*, Wang B, Huang YZ*. Remodeling Tumor Immune Microenvironment (TIME) for Glioma Therapy Using Multi-Targeting Liposomal Codelivery. Journal for ImmunoTherapy of Cancer 2020, in press. DOI: 10.1136/jitc-2019-000207 

2.Zhao YG, Yang YT, Zhang JX, Wang R, Cheng BY, Kalambhe D, Wang YS, Gu ZY, Chen DY*, Wang B*, Huang YZ*. Lactoferrin-mediated macrophage targeting delivery and patchouli alcohol-based therapeutic strategy for inflammatory bowel diseases. Acta Pharmaceutica Sinica B 2020, in press 

3.Chen BF, Gao A, Tu B, Wang YH, Yu XL, Wang YS, Xiu YF, Wang B, Wan YK, Huang YZ* Metabolic modulation via mTOR pathway and anti-angiogenesis remodels tumor microenvironment using PD-L1-targeting codelivery. Biomaterials, 2020. 255:120187 

4.Yin WM, Zhao YG, Kang XJ, Zhao PF, Fu X, Mo XP, Wang YH, Wan YK, Huang YZ*. BBB-penetrating codelivery liposomes treat brain metastasis of non-small cell lung cancer with EGFRT790M mutation. Theranostics 10(14): 6122 

5.Wang HR, Huang YZ*. Combination Therapy Based on Nano Codelivery for Overcoming Cancer Drug Resistance. Medicine in Drug Discovery, 2020: 100024 

6.Chang Y, Jiang J, Chen W, Yang W, Chen L, Chen P, Shen J, Qian S, Zhou T, Wu LF, Hong L, Huang YZ*, Li F*. Biomimetic metal-organic nanoparticles prepared with a 3D-printed microfluidic device as a novel formulation for disulfiram-based therapy against breast cancer. Applied Materials Today 2020, 18: 100492 

7.Zhang JX, Zhao YG, Hou T, Zeng H, Kalambhe C, Wang B*, Shen X, Huang YZ*. Macrophage-based nanotherapeutic strategies in ulcerative colitis. Journal of Controlled Release 2020, 320:363 (Back cover) 

8.Tu B, Zhang M*, Liu T, Huang YZ*. Nanotechnology-Based Histone Deacetylase Inhibitors for Cancer Therapy. Frontiers in Cell and Developmental Biology 2020, 8: 400 

9.Asrorov AM, Gu Z, Min KA, Shin MC*, Huang YZ* Advances on Tumor-Targeting Delivery of Cytotoxic Proteins. ACS Pharmacology & Translational Science 2020, 3(1): 107 

10.Ouyang X, Wang X, Kraatz HB, Ahmadi S, Gao J, Lv Y, Sun X*, Huang YZ*. A Trojan horse biomimetic delivery strategy using mesenchymal stem cells for PDT/PTT therapy against lung melanoma metastasis. Biomaterials Science 2020, 8: 1160 

11.Zhong HH, Wang HY*, Li J, Huang YZ*. TRAIL-based gene delivery and therapeutic strategies Acta Pharmacologica Sinica, 2019, 40: 1373 

12.Sun XY*, Zeng LH, Huang YZ*. Transcutaneous Delivery of DNA/mRNA for Cancer Therapeutic Vaccination. Journal of Gene Medicine 2019, 21(7): e3089 

13.Wang HR, Tang YS, Fang YF, Zhang M, Wang HY, He ZD, Wang B, Xu Q, and Huang YZ*. Reprogramming Tumor Immune Microenvironment (TIME) and 2 Metabolism via Biomimetic Targeting Codelivery of Shikonin/JQ1. Nano Letters 2019, 19(5):2935 

14.Zhang WY, Kang XJ, Yuan B, Wang HY, Zhang T, Shi MJ, Zheng ZN, Zhang YH, Peng CY, Fan XM, Shen YQ, Huang YZ*. Nano-structural effects on gene transfection: large, botryoid-shaped nanoparticles enhance DNA delivery via macropinocytosis and effective dissociation, Theranostics 2019, 9(6):1580-98 

15.Chang Y, Yao S, Chen YF, Huang JJ, Wu AH, Zhang M, Xu Fan, Li F ang Huang YZ*. Genetically-engineered protein prodrug-like nanoconjugates for tumor-targeting biomimetic delivery via a SHEATH strategy. Nanoscale 2019, 11: 611-621. 

16.Jin HY, He Y, Zhao PF, Hu Y*, Tao J, Chen J, Huang YZ*. Targeting lipid metabolism to overcome EMTassociated drug resistance via integrin β3/FAK pathway and tumor-associated macrophage repolarization using legumain-activatable delivery. Theranostics 2019, 9(1): 265-278 (Front cover). 

17.Chen W, Yang W, Chen PY, Huang YZ*, Feng L*. Disulfiram Copper Nanoparticles Prepared with a Stabilized Metal Ion Ligand Complex Method for Treating Drug-Resistant Prostate Cancers. ACS Appl. Mater. Interfaces 2018, 10(48): 41118-41128 

18.Zhao PF, Wang HY, Wu AH, Rao YF, and Huang YZ*. Roles of Albumin-Binding Proteins in Cancer Progression and Biomimetic Targeted Drug Delivery. Chembiochem 2018, 19(17): 1796-1805. 

19.Yin WM, Yu XL, Kang XJ, Zhao YG, Zhao PF, Jin HY, Fu XH, Wan YK*, Peng CY, and Huang YZ*. Remodeling Tumor-Associated Macrophages and Neovascularization Overcomes EGFRT790M-Associated Drug Resistance by PD-L1 Nanobody-Mediated Codelivery. Small 2018, 14(47): 1802372. 

20.Mo XP, Zheng ZN, He Y, Zhong HH, Kang XJ, Shi MJ, Liu TB, Jiao Z, Huang YZ*. Antiglioma via regulating oxidative stress and remodeling tumor-associated macrophage using lactoferrin-mediated biomimetic codelivery of simvastatin/fenretinide. Journal of Controlled Release 2018, 287: 12-23. 

21.Kang XJ, Zheng ZN, Liu ZH, Wang HY, Zhao YG, Zhang WY, Shi MJ, He Y, Cao Y, Xu Q*, Peng CY, Huang YZ*. Liposomal Codelivery of Doxorubicin and Andrographolide Inhibits Breast Cancer Growth and Metastasis. Molecular Pharmaceutics 2018, 15, 1618?1626. 

22.Zhao PF, Wang YH, Kang XJ, Wu AH, Yin WM, Tang YS, Wang JY, Zhang M, Duan Y and Huang YZ*. Dual-Targeting Biomimetic Delivery for Antiglioma via Remodeling Tumor Microenvironment and Directing Macrophage-Mediated Immunotherapy. Chemical Science 2018, 2674–2689 (Back front cover) 

23.Xu F, Zhong HH, Chang Y, Li DD, Jin HY, Zhang M, Wang HY, Jiang C, Shen YQ, Huang YZ*. Targeting death receptors for drug-resistant cancer therapy: Codelivery of pTRAIL and monensin using dual-targeting and stimuliresponsive self-assembling nanocomposites. Biomaterials 2018, 158:56-73 

24.Li DD, Zhang M, Xu F, Chen YZ, Chen BF, Chang Y, Zhong HH, Jin HY, Huang YZ*. Biomimetic albumin-modified gold nanorods for photothermo-chemotherapy and macrophage polarization modulation. Acta Pharmaceutica Sinica B 2018, 8(1): 74-84 (Back front cover) 

25.Chen YZ, Zhang M, Min KA, Wang HY, Shin MC*, Li F, Yang V, Huang YZ*. Improved Protein Toxin Delivery Based on ATTEMPTS Systems. Current Drug Targets 2018, 19(4): 380-392 

26.He Y, Li F*, Huang YZ*. Smart Cell-Penetrating Peptide-Based Techniques for Intracellular Delivery of Therapeutic Macromolecules. Adv Protein Chem Struct Biol. 2018;112:183-220 

27.Peng HG, Chen BF, Huang W, Tang YB, Jiang YF, Zhang WY, Huang YZ*. Reprogramming Tumor-Associated Macrophages to Reverse EGFR(T790M) Resistance by Dual-Targeting Codelivery of Gefitinib/Vorinostat. Nano Letters 2017, 17(12): 7684-90 

28.Zhao PF, Yin WM, Wu AH, Tang YS, Wang JY, Pan ZZ, Lin TT, Zhang M, Chen BF, Duan Y, Huang YZ*. Dual-Targeting to Cancer Cells and M2 Macrophages via Biomimetic Delivery of Mannosylated Albumin Nanoparticles for Drug-Resistant Cancer Therapy. Advanced Functional Materials 2017, 27(44): 1700403 (Front Cover) 

29.Chen YZ, Zhang M, Jin HY, Li DD, Xu F, Wu AH, Wang JY, Huang YZ*. Glioma Dual-Targeting Nanohybrid Protein Toxin Constructed by Intein-Mediated Site-Specific Ligation for Multistage Booster Delivery. Theranostics 2017, 7(14): 3489-503 

30.Xu JJ, Xu BH, Tao J, Yang YX, Hu Y*, Huang YZ*. Microneedle-Assisted, DC-Targeted Codelivery of pTRP-2 and Adjuvant of Paclitaxel. Small 2017, 13(28): 1700666 

31.Chen YZ, Zhang M, Jin HY, Tang YS, Wang HY, Xu Q, Li YP, Li F, Huang YZ*. Intein-mediated site-specific synthesis of tumor-targeting protein delivery system: Turning PEG dilemma into prodrug-like feature. Biomaterials 2017, 116: 57-68 

32.Tang YS, Liang JM, Wu AH, Chen YZ, Zhao PF, Lin TT, Zhang M, Xu Q*, Wang JM*, Huang YZ*. Co-Delivery of Trichosanthin and Albendazole by Nano-Self-Assembly for Overcoming Tumor Multidrug-Resistance and Metastasis. ACS Applied Materials & Interfaces 2017, 9(32): 26648-64 

33.Pan ZZ, Kang XJ, Zeng YE, Zhang WY, Peng HG, Wang JY, Huang W, Wang HY*, Shen YQ, Huang YZ*. A mannosylated PEI–CPP hybrid for TRAIL gene targeting delivery for colorectal cancer therapy. Polymer Chemistry 2017, 8(35): 5275-85 (Front Cover) 

34.Chen YZ, Zhang M, Jin HY, Tang YS, Wu AH, Xu Q, Huang YZ*. Prodrug-Like, PEGylated Protein Toxin Trichosanthin for Reversal of Chemoresistance. Molecular Pharmaceutics 2017, 14(5): 1429-38 

35.Tan J, Wang HY, Xu F, Chen YZ, Zhang M, Peng HG, Sun X*, Shen YQ, Huang YZ*. Poly-γ-glutamic acid-based GGT-targeting and surface camouflage strategy for improving cervical cancer gene therapy. Journal of Materials Chemistry B 2017, 5:1315-1327 

36.Kan XJ, Wang HY, Peng HG, Chen BF, Zhang WY, Wu AH, Xu Q*, Huang YZ*. Codelivery of dihydroartemisinin and doxorubicin in mannosylated liposomes for drug-resistant colon cancer therapy. Acta Pharmacologica Sinica 2017, 38(6): 885-96 (Serving as Co-Guest Editors for the featured issue) 

37.Zhang M, Liu E, Cui Y, Huang YZ*. Nanotechnology-based combination therapy for overcoming multidrug-resistant cancer. Cancer Biology & Medicine 2017, 14(3): 212-27 

38.Wang HY, Moon C, Shin MC, Wang YP, He HN, Yang V*, Huang YZ*. Heparin-Regulated Prodrug-Type Macromolecular Theranostic Systems for Cancer Therapy. Nanotheranostics 2017, 1(1): 114-30 

39.Lin TT, Zhao PF, Jiang YF, Tang YS, Jin HY, Pan ZZ, He HN, Yang V, Huang YZ*. Blood–Brain-Barrier-Penetrating Albumin Nanoparticles for Biomimetic Drug Delivery via Albumin-Binding Protein Pathways for Antiglioma Therapy. ACS Nano 2016, 10:9999-10012 

40.Cui YN, Zhang M, Zeng F, Jin HY, Xu Q, Huang YZ*. Dual-targeting magnetic PLGA nanoparticles for codelivery of paclitaxel and curcumin for brain tumor therapy. ACS Applied Materials & Interfaces 2016, 8: 32159-32169 

41.Lin TT, Liu EG, He HN, Shin MC, Moon C, Yang V*, Huang YZ*. Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides. Acta Pharmaceutica Sinica B 2016, 6: 352–358 (Back front cover) 

42.Pan ZZ, Wang HY, Zhang M, Lin TT, Zhang WY, Zhao PF, Tang YS, Xiong Y, Zeng YE* and Huang YZ*. Nuclear-targeting TAT-PEG-Asp8-doxorubicin polymeric nanoassembly to overcome drug-resistant colon cancer. Acta Pharmacologica Sinica 2016, 37: 1110–1120 (Editor choice) 

43.Wang HY, Jiang YF, Peng HG, Chen YZ, Zhu PZ, Huang YZ*. Recent Progress in microRNA Delivery for Cancer Therapy by Non-viral Synthetic Vectors. Advanced Drug Delivery Reviews 2015, 81:142-60 

44.Wang YP, Lin TT, Zhang WY, Jiang YF, Jin HY, Yang VC, Chen Y and Huang YZ*. A Prodrug-type, MMP-2-targeting Nanoprobe for Tumor Detection and Imaging. Theranostics 2015, 5:787-795 

45.Hu Y, Xu BH, Xu JJ, Shou D, Liu EG, Gao JQ, Liang WQ, and Huang YZ*, Microneedle-assisted Dendritic Cell-targeted Nanoparticles for Transcutaneous DNA Immunization. Polymer Chemistry 2015, 6: 373-379 (Front Cover) 

46.Liang JM, Zeng F, Zhang M, Pan ZZ, Chen YZ, Zeng YE, Xu Y, Xu Q*, Huang YZ*. Green synthesis of hyaluronic acid-based silver nanoparticles and their enhanced delivery to CD44+ cancer cells. RSC Advances 2015,5, 43733-43740 

47.Jiang YF, Lu JY, Wang YP, Zeng F, Wang HY, Peng HG, Huang M, Jiang HL, Luo C* and Huang YZ*, Molecular-Dynamics-Simulation-Driven Design of a Protease-Responsive Probe for In Vivo Tumor Imaging. Advanced Materials 2014, 26: 8174-8 

48.Wang YP, Jiang YF, Zhang M, Tan J, Liang JM, Wang HX, Li YP, He HN, Yang V*, Huang YZ*. Protease-activatable Hybrid Nanoprobe for Tumor Imaging. Advanced Functional Materials 2014, 24: 5443-53. 

49.Wang HX, Zhao YX, Wang HY, Gong JB, He HN, Yang V*, Huang YZ*. Low-Molecular-Weight Protamine-Modified PLGA Nanoparticles for Overcoming Drug-Resistant Breast Cancer. Journal of Controlled Release 2014, 192: 47–56 

50.Wang HY, Wang HX, Liang JM, Jiang YF, Guo QQ, Peng HG, Xu Q, Huang YZ*. Cell-penetrating Apoptotic Peptide/p53 DNA Nanocomplex as Adjuvant Therapy for Drug-resistant Breast Cancer. Molecular Pharmaceutics 2014, 11:3352-60 

51.Wang HY, Li F*, Du C, Wang HX, Mahato RI, Huang YZ*. Doxorubicin and Lapatinib Combination Nanomedicine for Treating Resistant Breast Cancer. Molecular Pharmaceutics 2014, 11: 2600-11 (Serving as Co-Guest Editors for the featured issue) 

52.Tan J, Cheong HS, Park YS, Kim HG, Zhang M, Moon C* and Huang YZ*. Cell-Penetrating Peptide-Mediated Topical Delivery of Biomacromolecular Drugs. Current Pharmaceutical Biotechnology. 2014, 15(3):231-9 (Serving as Guest Editor for the featured issue) 

53.Wang Z, Chen YZ, Liu EG, Gong JB, Shin MC, Huang YZ*. CPP-mediated Protein Delivery in a Noncovalent Form: Proof-of-Concept for Percutaneous and Intranasal Delivery. Protein Peptide Letters 2014, 21:1129-36. 

54.Huang YZ*, Jiang YF, Wang HY, Wang JX, Shin MC, Byun Y, He HN, Liang YQ, and Yang V*. Curb challenges of the "Trojan Horse" approach: Smart strategies in achieving effective yet safe cell-penetrating peptide-based drug delivery. Advanced Drug Delivery Reviews 2013, 65: 1299-315. 

55.Wang HY, Guo QQ, Jiang YF, Liu EG, Zhao YX, Wang HX, Li YP*, Huang YZ*. Co-delivery of Cell-permeable Chimeric Apoptosis AVPIR8 Peptide/p53 DNA for Cocktail Therapy. Advanced Functional Materials 2013, 23: 6068-75. 

56.Guo QQ, Wang HY, Zhao YX, Liu EG, Wang HX, Hua HY, Huang YZ*. Cell-penetrating Albumin Conjugates for Enhanced Doxorubicin Delivery. Polymer Chemistry 2013, 4: 4584-4587. (Highlighted as “Paper of the Week”) 

57.Wang Y, Liu EG, Sun XY, Huang PY, Long H, Wang H, Yu X, Zheng CH, Huang YZ*. Pluronic L61 as a long-circulating modifier for enhanced liposomal delivery of cancer drugs. Polymer Chemistry 2013, 4: 2958-2962. 

58.Yan L, Wang HY, Jiang YF, Liu JH, Wang Z, Yang YX, Huang SW, Huang YZ*. Cell-penetrating peptide-modified PLGA nanoparticles for enhanced nose-to-brain macromolecular delivery. Macromolecular Research 2013, 21: 435-441. 

59.Liu JH, Zhao YX, Guo QQ, Wang Z, Wang HY, Yang YX, Huang YZ*. TAT-modified nanosilver for combating multidrug-resistant cancer. Biomaterials 2012, 33: 6155-61. 

60.Yang YX, Jiang YF, Wang Z, Liu JH, Yan L, Ye JX, Huang YZ*. Skin-permeable quaternary nanoparticles with layer-by-layer structure enabling improved gene delivery. Journal of Materials Chemistry 2012, 22: 10029-34. 

61.Wang S, Wang H, Liang W*, Huang YZ*. An injectable hybrid nanoparticle-in-oil-in-water submicron emulsion for improved delivery of poorly soluble drugs. Nanoscale Research Letters 2012, 7:219 

62.Yang YX, Gao Y, Chen L, Huang YZ*, and Li YP*. Downregulation of survivin expression and enhanced chemosensitivity of MCF-7 cells to adriamycin by PDMAE/survivin shRNA complex nanoparticles. International Journal of Pharmaceutics 2011, 405:188-195 

63.Dong SY, Wang S, Zheng CH, Liang W*, and Huang YZ*. An in situ-forming, solid lipid/PLGA hybrid implant for long-acting antipsychotics. Soft Matter 2011, 7:5873-5878 

A full publication list is available via Google Scholar. https://scholar.google.com/citations?user=Z-yoe34AAAAJ 

Book Chapter: 

1.Zhang M, Liu EG*, Huang YZ*. Magnetically Responsive Nanomedicine. Chapter 7 in Stimuli-Responsive Nanomedicine ? 2020 Jenny Stanford Publishing Pte. Ltd. 

2.Zhao PF, Li F*, Huang YZ*. Nanotechnology-based targeted drug delivery systems and drug resistance in colorectal cancer. Chapter 10 in Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies ?2020 Elsevier 

3.Liu EG, Zhang M, Huang YZ*. Pharmacokinetics and Pharmacodynamics (PK/PD) of Bionanomaterials. Chapter 1 in Biomedical Nanomaterials.? 2016 Wiley-VCH 

4.Mo XP, Liu EG, Huang YZ*. The intra-brain distribution of brain targeting delivery systems. Chapter in Brain Targeted Drug Delivery System ?2018 Elsevier