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Faculty and Staff
Faculty and Staff
Feng Linyin

Director of Department of Pharmacology Ⅱ,PI,Ph.D candidate supervisor
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Mailing Address:
555 Zu Chong Zhi Road , Zhang Jiang Hi-Tech Park, Pudong, Shanghai

Feng Linyin obtained her Ph.D. in Shanghai Medical University in 1991. She jointed Shanghai Institute of Brain Research as a postdoctor. In 1997, Feng was promoted to the professor. She undertake a number research projecsts from National Basic Research Program of China, National Basic Research Program of China and published more than 40 papers in the international academic journals.

1991 Ph. D.,Dept. of Histology and Embryology,Shanghai Medical University
1985 Master Degree for Sciences,Dept. of Anatomy,Jiangxi Medical College
1982 M.D.,Dept. of Medicine,Jiangxi Medical College

Postdoctoral Training:
02/1992 - 07/1994 Postdoctoral Fellow,Shanghai Brain Research Institute,Chinese Academy of Sciences
Advanced Training:
02/1994 - 06/1994 Dept. of Biochemistry,Hong Kong University(Training program of International Brain Research Organization)
Academic Appointments:
04/2004 - present Professor,Shanghai Institute of Materia Medica,Chinese Academy of Scineces
11/1999 - 03/2004 Principle Investigator,Head of Molecular Neurobiology,Institute of Neuroscience,Chinese Academy of Sciences
05/1999 - 11/1999 Professor,Shanghai Brain Research Institute,Chinese Academy of Sciences
07/1994 - 04/1999 Associate Professor,Shanghai Brain Research Institute,Chinese Academy of Sciences
01/1987 - 12/1988 Lecturer,Department of Anatomy,Jiangxi Medical College
01/1983 - 12/1986 Teaching Assistant,Department of Anatomy,Jiangxi Medical College

Research Directions
1.  Drug screening,target identification and pharmalogical mechanism study for neurodegenerative diseases
(1) Study on the role of glia cells in pathological and pharmalogical action process of brain ischemic and Parkinson's disease
(2) Study on the epigenetic regulation in brain ischemic and Parkinson's disease
2.  Screen and discovery small molecule compounds for regulating of proliffiration and differentiation of neural stem cells and mesenchymal stem cells

Social Titles
1997 - present Member of Standing Council of Shanghai Society for Neuroscience
2001 - present Member of Council of Shanghai Society for Cell Biology
1997 - 2004    Member of Council of Shanghai Society of Physiology
1998 - 2001    Secretary-General,member of Standing council of Shanghai Society for Neuroscience
2007 - present Member of Council of Chinese Pharmacology Society

Awards & Honors
03/2006 - present Chief,Department of Neuropharmacology,Shanghai Institute of Materia Medica,Chinese Academy of Sciences.
11/1999 - 11/2002 Deputy Director,Institute of Neuroscience,Chinese Academy of Sciences.
05/1996 - 10/1999 Deputy Director,Shanghai Brain Research Institute,Chinese Academy of Sciences.

1. Cx43 as the stabilizer of astrocytes in ischemic stroke to facilitate neuronal recovery
2. Paeoniflorin protect brain ischemia in vitro by transactivation of epidermal growth factor receptor mediated by adenosine A1 receptor
3. Study on the neuroprotective effects and mechanisms of LLDT-67 in PD
4. The study on the effects and mechanisms of PF-modified compound in brain ischemia
5. Evaluation and mechanisms study of nanoparticle delivery system for brain targeting drug delivery

Grants & Research Projects
1.National basic Research Program of China,The study of nano-drug delivery system for digonosis and therapy of neurodegeneration disease,Head,2007.01-2010.12
2.the National Science and Technology Major Projects for “Major New Drugs Innovation and Development",The study of leading compounds for treatment of neural diseases based on neuroglia-targeting,Head,2014.01-2016.12
3.the National Science and Technology Major Projects for “Major New Drugs Innovation and Development",The study of anti-stroke drug candidates isolated from Paeoniae Radix,Head,2009.01-2010.12
4.the Scientific Innovation Project of the Chinese Academy of Sciences,Study of small molecues for regulating differentiation of neural stem cell,Head,2011.01-2015.12


1.Huang L., Wu DD, Feng L.*(2013) Modulation of A2a Receptor antagonist on D2 Receptor internalization and ERK phosphorylation Acta Pharmacologica Sinica, 34: 1292–1300; doi: 10.1038/aps.2013.87; published online 12 Aug 2013  

2.Wu DD, Huang L, Zhang L, Wu LY, LI YC, Feng L* (2012) LLDT-67 attenuates MPTP-induced neurotoxicity in mice by up-regulating NGF expression. Acta Pharmacologica Sinica, 33: 1187–1194; published online 3 Sep 2012  

3.Zhang P, Hu L, Yin Q, Feng, L*, Li Y* (2012) Transferrin-Modified c[RGDfK]-Paclitaxel Loaded Hybrid Micelle for Sequential Blood-Brain Barrier Penetration and Glioma Targeting Therapy. Molecular Pharmaceutics 39: 04/04 18:04:03  

4.Zhang P, Hu L, Yin Q, Zhang ZW, Feng, L*, Li Y * (2012) Transferrin-conjugated polyphosphoester hybrid micelle loading paclitaxel for brain-targeting delivery: Synthesis, preparation and in vivo evaluation. Journal of Controlled Release [Epub ahead of print]  

5.Jin L, Zhang LM, Xie KQ, Ye Y, Feng L*.(2011) Paeoniflorin suppresses the expression of ICAM-1 in endotoxin-treated human monocytic cells. Br J Pharmacol. 164: 694–703. [Epub ahead of print]  

6.Zhan C, Li B, Hu, L Wei X, Feng L, Fu W, Lu W, (2011) Micelle-Based Brain- Targeted Drug Delivery Enabled by a Nicotine Acetylcholine Receptor Ligand. Angew Chem Int Ed Engl. 50: 5482 –5485 [Epub ahead of print]  

7.Zhang P, Hu L., Wang Y,, Wan J., Feng L*, Li Y. * (2010) Poly (ε-caprolactone)- block -poly(ethyl ethylene phosphate) micelles for brain targeting drug delivery: in vitro and in vivo valuation. Pharmaceutical Research, 27: 2657~2669  

8.Ji Y., Lu Y., Yang F., Shen W., Tang T. TT., Feng L., Duan S., & Lu B. (2010) Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons. Nature Neuroscience 302 – 309  

9.Huang R, Ke W, Liu Y, Wu D, Feng L, Jiang C, Pei Y. ( 2010) Gene therapy using lactoferrin-modified nanoparticles in a rotenone-induced chronic Parkinson model. J Neurol Sci. 290 (1-2):123-30. Epub 2009 Nov 11.  

10.Zang Y, Yu LF,, Nan FJ, Feng L, Li J.(2009)AMP-activated Protein Kinase Is Involved in Neural Stem Cell Growth Suppression and Cell Cycle Arrest by – Aminoimidazole -4- carboxamide -1-_-D-ribofuranoside and Glucose Deprivation by Down-regulating Phospho-retinoblastoma Protein and Cyclin D. J Biol Chem. 284(10) 6175–6184  

11.Xie KQ., Zhang LM., Cao Y., Zhu J., Feng L.* (2009) Adenosine A1 receptor-mediated transactivation of the EGF receptor produces a neuroprotective effect on cortical neurons in vitro. Acta Pharmacologica Sinica 30: 889–898