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Faculty and Staff
Faculty and Staff
Zhang Haiyan

Principle Investigator
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Mailing Address:
555 Zu Chong Zhi Road , Zhang Jiang Hi-Tech Park, Pudong, Shanghai

09/1994–09/1998  Zhangzhou University B.S. degree
09/1998–09/2003  Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Ph.D degree

08/2003–03/2005  Mayo Clinic, Jacksonville, Florida, USA, Research Fellow
04/2005–02/2007  Wake Forest University, North Carolina, USA, Research Fellow/Associate
02/2007–06/2009  Department of Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Associate Professor
06/2009–now       Department of Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Professor, Principle Investigator

Research Directions
Mainly focuses on study of pathogenesis of Alzheimer’s disease (AD) and discovery of novel therapeutic strategies for AD, vascular dementia (VaD) and ischemic stroke. The recent research interestsof Dr. Zhang’s group are to identify and validate key drug targetsagainst Aβ oligomer associated aberrant signaling pathway, as well as developing potential drug candidates for the treatment of AD or ischemic stroke based on eitheractive natural productsor important therapeutic targets (AChE, Aβ , PSD95-nNOS, SIRT).

Social Titles
Anti-aging and Alzheimer's Professional Committee, Chinese Pharmaceutical Society, committee member
Acta Pharmacologica Sinica, Member of Editorial board
Journal of Alzheimer’ s disease, Member of Editorial board

Awards & Honors
2010,  Chinese Pharmaceutical Society Sevier Young Faculty Award
2010,  SA-SIBS Outstanding Youth Talent Scholarship

Published 58 papers in SCI cited journals (Trends Pharmacol Sin, Neurobiol Aging, Free RadicBiol& Med, J Alzheimer Dis, et al), applied 14 invention patents with 4 authorized.

Grants & Research Projects
  1. Shanghai Science and Technology Development Funds,  Molecular mechanisms involved between Aβ  and mitochondrial function, Project Leader, 2010.4-2012.4
  2. National Natural Science Foundation of China,  Relationship between intracellular Aβ and mitochondrial function in APP transgenic mice and therapeutic strategies. Project Leader, 2009.1-2011.12
  3. National Natural Science Foundation of China, Role of Insulin/IGF-1 Signaling in the pathogenesis of Alzheimer’ s disease and associated therapeutic strategies, Project Leader, 2012.1-2015.12
  4. National Science & Technology Major Project, Key New Drug Creation and Manufacturing Program” of China, Research in novel anti-Alzheimer’s disease candidates?YLV-1,  Project Leader, 2009.0-2010.12
  5. National Science & Technology Major Project, Key New Drug Creation and Manufacturing Program” of China, Preclinical Research in novel anti-Alzheimer’s disease candidates?YLV-1, Project Leader 2013.1-2015.12


(since 2009)

  1. GuoXJ, Tian XS, Ruan Z, Chen YT, Wu L, Gong Q, Wang W, Zhang HY*. Dysregulation of Neurotrophic and Inflammatory Systems Accompanied by Decreased CREB Signaling in Ischemic Rat Retina. Exp Eye Res 2014;125:156-163.
  2. Tian XS, GuoXJ, Ruan Z, Lei Y, Chen YT, Wu L, Gong Q, Wang W, Zhang HY*. Long-term vision and non-vision dominant behavioral deficits in the 2-VO rats are accompanied by time and regional glial activation in the white matter. PLos one 2014;9:e101120.
  3. Huang XT, Qian ZM, He X, Gong Q, Wu KC, Jiang LR, Lu LN, Zhu ZJ, Zhang HY, Yung WH, Ke Y. Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease. Neurobiol Aging. 2014; 35: 1045-54.
  4. Tao YM, Fang L, Yang YM, Jiang HL, Yang HY, Zhang HY*, Zhou H*. Quantitative proteomic analysis reveals the neuroprotective effects of huperzine A for amyloid beta treated neuroblastomaN2a cells. Proteomics. 2013; 13(8): 1314-24.
  5. Xing WQ, Fu Y, Shi ZX, Lu D, Zhang HY*, Hu YH*. Discovery of novel 2,6-disubstitutedpyridazinone derivatives as acetylcholinesterase inhibitors. Eur J Med Chem. 2013; 63: 95-103.
  6. ZouYQ, Xu L, Chen WY, Zhu YP, Chen TT, Fu Y, Li L, Ma LP, Xiong B, Wang X, Li J, He JH, Zhang HY*, Xu YC*, Li J*, Shen JK*. Discovery of pyrazole as C-terminus of selective BACE1 inhibitors. Eur J Med Chem. 2013; 68: 270-83.
  7. Zhang B, Tang XC, Zhang HY*. Alternations of central insulin-like growth factor-1 sensitivity in APP/PS1 transgenic mice and neuronal models. J Neurosci Res. 2013; 91(5): 717-25.
  8. GuoXJ, Chen YT, Liu QF, Wu J, Wang LY, Tang XC, Zhao WM*, Zhang HY*. Ac-cel, a novel antioxidant, protects against hydrogen peroxide-induced injury in PC12 cells via attenuation of mitochondrial dysfunction. J MolNeurosci. 2013; 50(3): 453-61.
  9. Wang LY, Wu J, Yang Z, Wang XJ, Fu Y, Liu SZ, Wang HM, Zhu WL, Zhang HY*, Zhao WM*. (M)- and (P)-bicelaphanol A, dimerictrinorditerpenes with promising neuroprotective activity from Celastrusorbiculatus. J Nat Prod. 2013; 76: 745-9.
  10. Wang XJ, Wang LY, Fu Y, Wu J, Tang XC, Zhao WM, Zhang HY*. Promising effects on ameliorating mitochondrial function and enhancing Akt signaling in SH-SY5Y cells by (M)-bicelaphanol A, a novel dimericpodocarpane type trinorditerpene isolated from Celastrusorbiculatus. Phytomedicine. 2013; 20(12):1064-70.
  11. Liang LF, Wang XJ, Zhang HY, Liu HL, Li J, Lan LF, Zhang W, GuoYW. Bioactive polyhydroxylated steroids from the Hainan soft coral SinulariadepressaTixier-Durivault. Bioorg Med ChemLett. 2013; 23(5): 1334-7.
  12. Tang Y, Fu Y, Xiong J, Li M, Ma GL, Yang GX, Wei BG, Zhao Y, Zhang HY, Hu JF. Casuarinines A-J, lycodine-type alkaloids from Lycopodiastrumcasuarinoides. J Nat Prod. 2013; 76(8): 1475-84.
  13. Yang L, Ye CY, Huang XT, Tang XC, Zhang HY*. Decreased accumulation of subcellular amyloid-β with improved mitochondrial function mediates the neuroprotective effect of huperzine A. J Alzheimers Dis. 2012; 31(1): 131-42.
  14. Gao X, Zheng CY, Qin GW, Tang XC, Zhang HY*. S-52, a novel nootropic compound, protects against β-amyloid induced neuronal injury by attenuating mitochondrial dysfunction. J Neurosci Res. 2012; 90(10): 1981-8.
  15. Wang Y, Tang XC, Zhang HY*. Huperzine A alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe/PS1dE9 transgenic mice. J Neurosci Res. 2012; 90: 508-17.
  16. Zhang HY*. New insights into huperzine A for the treatment of Alzheimer's disease. ActaPharmacol Sin. 2012; 33: 1170-5.
  17. Jiang CS, GuoXJ, Gong JX, Zhu TT, Zhang HY*, GuoYW*. Synthesis and biological evaluation of 21-arylidenepregnenolone derivatives as neuroprotective agents. Bioorg Med ChemLett. 2012; 22: 2226-9.
  18. Chen BE, Ye F, Yu L, JiaGF, Huang XT, Zhang XJ, Peng SY, Chen K, Wang MN, Gong SZ, Zhang RH, Yin JY, Li HY, Yang YM, Liu H, Zhang JW, Zhang HY, Zhang A, Jiang HL, Luo C, Yang CG. Development of Cell-Active N(6)-Methyladenosine RNA DemethylaseFTO Inhibitor. J Am Chem Soc. 2012; 134: 17963-71.
  19. Dong K, Pu JX, Zhang HY, Du X, Li XN, Zou J, Yang JH, Zhao W, Tang XC, Sun HD. Dibenzocyclooctadienelignans from Kadsurapolysperma and their antineurodegenerative activities. J Nat Prod. 2012; 75: 249-56.
  20. Yao LG, Zhang HY, Liang LF, GuoXJ, Mao SC, GuoYW. Yalongenes A and B, Two New Cembranoids with Cytoprotective Effects from the Hainan Soft Coral SarcophytontrocheliophrumMarenzeller. Helv. Chim. Acta. 2012; 95: 235-9.
  21. Chen HD, Ding YQ, Yang SP, Li XC, Wang XJ, Zhang HY, Ferreira D, Yue JM. Morusalbanol A, a neuro-protective Dielse-Alder adduct with an unprecedented architecture from Morusalba. Tetrahedron. 2012; 68: 6054-8.
  22. Yang JH, Zhang HY, Wen J, Du X, Chen JH, Zhang HB, Xiao WL, Pu JX, Tang XC, Sun HD. Dibenzocyclooctadienelignans with antineurodegenerative potential from Kadsuraananosma. J Nat Prod.2012; 74: 1028-35.
  23. Wang Y, Yang YS, Tang XC, Zhang HY*. T33, a novel peroxisome proliferator-activated receptor γ/α agonist, exerts neuroprotective action via its anti-inflammatory activities. ActaPharmacol Sin. 2011; 32: 1100-8.
  24. Wang JR, Liu HL, Kurtán T, Mándi A, Antus S, Li J, Zhang HY, GuoYW. Protolimonoids and norlimonoids from the stem bark of Toonaciliata var. pubescens. Org BiomolChem.2011; 9: 7685-96.
  25. Yang JH, Zhang HY, Du X, Wang W, Xiao WL, Wen J, Pu JX, Tang XC, Sun HD. New dibenzocyclooctadienelignans from the Kadsuraananosma. Tetrahedron. 2011; 67: 4498-504.
  26. Wang J, Zhang HY*, Tang XC. Huperzine A Improves Chronic Inflammation and Cognitive Decline in Rats With Cerebral Hypoperfusion. J Neurosci Res. 2010; 88: 807-15.
  27. Wang Y, Huang LQ, Tang XC, Zhang HY*. Retrospect and prospect of active principles from Chinese herbs in the treatment of dementia. ActaPharmacol Sin. 2010; 31(6): 649-64.
  28. Shi YF, Zhang HY*, Wang W, Fu Y, Xia Y, Tang XC, Bai DL, He XC. Novel 16-substituted bifunctional derivatives of huperzine B: multifunctional cholinesterase inhibitors. ActaPharmacol Sin. 2009; 30(8): 1195-203.
  29. Gao X, Zheng CY, Yang L, Tang XC, Zhang HY*. HuperzineA Protects Isolated Rat Brain Mitochondria against β-Amyloid Peptide. Free Radical Biol& Med. 2009; 46(11): 1454-62.
  30. Zhu YP, Xiao K, Ma LP, Xiong B, Fu Y, Yu HP, Wang W, Wang X, Hu DY, Peng HL, Li JY, Gong Q, Chai Q, Tang XC, Zhang HY*, Li J, Shen JK. Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and b-secretase. Bioorgan Med Chem. 2009; 17(4): 1600-13.
  31. Wang J, Zhang HY, Tang XC. Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment. ActaPharmacol Sin. 2009; 30: 879-88.
  32. Yuan T, Yang SP, Zhang HY, Liao SG, Wang W, Wu Y, Tang XC, Yue JM. Phenolic compounds with cell protective activity from the fruits of Livistonachinensis. J Asian Nat Prod Res. 2009; 11(3):243-9.
  33. Zhu YP, Xiao K, Yu HP, Ma LP, Xiong B, Zhang HY, Wang X, Li JY, Li J, Shen JK. Discovery of potent beta-secretase (bace-1) inhibitors by the synthesis of isophthalamide-containing hybrids. ActaPharmacol Sin. 2009; 30(2): 259-69.
  34. Zhu Q, Tang CP, KeCQ, Wang W, Zhang HY, Ye Y. Sesquiterpenoids and Phenylpropanoids from Pericarps of Illiciumoligandrum. J Nat Prod. 2009; 72: 238-42.