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研究队伍
姓 名:
 于海军
性 别:
 男
职 称:
 研究员
学 历:
 博士
电 话:
 021-20231000-1521
传 真:
 
电子邮件:
 hjyu@simm.ac.cn
个人主页:
通讯地址:
 上海浦东张江海科路501号 201203
简历:

主要从事新型递药系统研究和药用功能辅料开发工作。研究成果主要包括:1)利用纳米免疫学原理,构建了系列新型纳米载药系统,激活肿瘤免疫效应并逆转肿瘤免疫抑制微环境,有效抗肿瘤转移和复发;2)构建了系列快速酸响应纳米载药系统克服肿瘤组织和细胞生理屏障,提高药物转运效率,显著改善肿瘤化疗和RNA干扰治疗效果;3)从分子、细胞和组织层面揭示了上述纳米载药系统抗肿瘤耐药和转移的关键作用机制。主持基金委“优青”基金、面上项目和科技部“973”课题等多项国家级科研项目。共发表第一/通讯作者论文30篇(IF>12的12篇),包括Nat Commun, Adv Mater, ACS Nano, Nano LettersAdv Funct Mater等重要期刊。申报中国发明专利11项,授权4项。在国内外重要学术会议作邀请或分会报告20余次

教育经历
1. 2001.09-2006.12,中国科学院长春应用化学研究所,生物医用高分子,博士
2. 1997.09-2001.07,内蒙古大学, 化学,本科,

工作经历

1. 2018.10-现在,课题组长,中科院上海药物研究所
2. 2016.10-现在,研究员,中科院上海药物研究所
3. 2012.05-2016.09,中科院上海药物研究所,副研究员
4. 2011.02-2012.04,日本东北大学,博士后(助手)
5. 2009.02-2011.01,美国德州大学西南医学中心癌症中心,博士后
6. 2007.02-2009.01,德国慕尼黑大学药学系,博士后


研究方向:
1. 新型药物递释系统和药用功能辅料开发
2. 智能纳米诊疗系统研究

专家类别:
研究员

职务:
课题组长

科研成果:

承担科研项目情况:

1.基金委面上项目,免疫检查点靶向纳米载药系统用于转移性肿瘤免疫协同治疗的研究(51873228);        
2.基金委优秀青年基金,纳米载药系统(31622025);        
3.基金委面上项目,肿瘤微环境自适性纳米载药系统抗乳腺癌转移及其作用机制研究(31671024);        
4.基金委面上项目,双重酸敏感多层阳离子胶束/RNA复合纳米粒的构建及其用于转移性乳腺癌分子靶向治疗的研究(81373359);                
5.科技部“973”课题,生物医用纳米材料的代谢过程及其分析方法研究(2013CB932704);        
6.基金委创新研究群体(参加),基于纳米技术的抗癌药物新型递释系统 (81521005)。
7.中国科学院青促会,药剂学(2014249);        
8.中国科学院药物创新研究院自主部署科研项目,聚乙二醇-奥沙利铂键合前药及其成药性研究(CASIMM0120162002);


社会任职:

1. 2018.10-现在,The Journal of Gene Medicine,编委
2. 2017.08-现在,Current Applied Polymer Science (Bentham Science),编委
3. 2017.01-现在,《药学学报》 青年编委
4. 2017.10-现在,中国抗癌协会纳米肿瘤学青年委员会,副主任委员
5. 2017.08-现在,中国医药生物技术协会纳米生物技术分会,常务委员
6. 2017.09-现在,中国药学会,高级会员
7. 2016.10-现在,中国毒理学会纳米毒理学青年委员会,委员


获奖及荣誉:

1. 2017年,科技部中青年科技创新领军人才
2. 2017年,中国药学会-赛诺菲青年生物药物奖
3. 2016年,国家基金委优秀青年基金
4. 2016年,科技部重点领域创新团队骨干成员
5. 2015年,国家自然科学基金委创新研究群体成员
6. 2015年,中国药学会科学技术奖一等奖(排名第四)
7. 2014年,中国药学会-中恒青年药剂学奖
8. 2013年,赛诺菲-上海生科院优秀青年人才奖
9. 2013年,中科院青年人才促进会
10. 2013年,上海市药学科技一等奖(排名第四)


代表论著:

代表性研究论文:

1.Zhihao Zhao#, Weiqi Wang#, Chenxi Li, Yiqiu Zhang, Tianrong Yu, Renfei Wu, Jiayue Zhao, Zhuang Liu, Jian Liu*, Haijun Yu*. Reactive Oxygen Species-Activatable Liposomes (RALP) Regulating Tumor Microenvironment for Photo/Chemo-Dynamic Therap. Adv Funct Mater, 2019. 1905013.

2.Madiha Saeed, Jing Gao, Haijun Yu*. Engineered Nanoparticles Combating the Pathophysiological Barriers for Improved Cancer Immunotherapy. Theranostics. 2019. doi:10.7150/thno.37568.

3.Haijun Yu*, Rongqin Huang, Yu Nie, Synthetic nucleic acid nanomedicines: a Chinese perspective (Editorial). The Journal of Gene Medicine. 2019;21:e3111.

4.Weiqi Wang, Madiha Sadeed, Yao Zhou, Lili Yang, Dangge Wang, Haijun Yu*, Non-viral gene delivery for cancer immunotherapy. The Journal of Gene Medicine. 2019;21:e3092.

5.Bing Feng,# Bo Hou,# Zhiai Xu, Madiha Saeed, Haijun Yu,* Yaping Li* Light-Inducible Nanocargos for Self-Amplified Drug Delivery and Combination Chemoimmunotherapy. Adv Mater, 2019, 1902960.

6.Li Lei, Zhiai Xu*, Xianli Hu, Yi Lai, Jie Xu, Bo Hou, Ya Wang, Haijun Yu*, Yang Tian, Wen Zhang*. Bioinspired Multivalent Peptide Nanotubes for Sialic Acid Targeting and Imaging-Guided Treatment of Metastatic Melanoma. Small. 2019,1900157.

7.Fangyuan Zhou,# Bing Feng,# Haijun Yu,* Dangge Wang, Tingting Wang, Yuting Ma, Siling Wang, Yaping Li*, Tumor Microenvironment-Activatable Prodrug Vesicles for Nano-enabled Cancer Immunotherapy Combining Immunogenic Cell Death Induction and CD47 Blockade. Adv Mater. 2018, 1805888.

8.Dangge Wang, Tingting Wang, Haijun Yu,* Bing Feng, Lei Zhou, Fangyuan Zhou, Bo Hou, Hanwu Zhang, Min Luo, Yaping Li*. Engineered Antibody Nanoparticles Overcome Immunological Tolerance to PD-L1 Blockade Therapy. Science Immunology 2019, 4, eaau6584.

9.Bing Feng#, Fangyuan Zhou#, Bo Hou, Dangge Wang, Tingting Wang, Yuanlei Fu, Yuting Ma, Haijun Yu*,Yaping Li*. Binary Cooperative Prodrug Nanoparticles Improve Immunotherapy by Synergistically Modulating Immune Tumor Microenvironment. Adv Mater. 2018, 1803001.

10.Tingting Wang#, Dangge Wang#, Haijun Yu*, Bing Feng, Fangyuan Zhou, Lei Zhou, Hanwu Zhang, Shi Jiao, Yaping Li*. A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors. Nat Commun, 2018,9:1532.

11.Fangyuan Zhou#, Bing Feng#, Tingting Wang, Dangge Wang, Zhirui Cui, Siling Wang,* Chunyong Ding, Zhiwen Zhang, Jian Liu, Haijun Yu,* and Yaping Li* Theranostic Prodrug Vesicles for Reactive Oxygen Species-Triggered Ultrafast Drug Release and Local-Regional Therapy of Metastatic Triple-Negative Breast Cancer. Adv. Funct. Mater. 2017, 1703674.

12.Tingting Wang, Dangge Wang, Jianping Liu, Bing Feng, Fangyuan Zhou, Hanwu Zhang, Lei Zhou, Qi Yin, Haijun Yu*, Yaping Li*. Acidity-Triggered Ligand-Presenting Nanoparticles To Overcome Sequential Drug Delivery Barriers to Tumors. Nano Letters. 2017, 17, 5429-5436.

13.Bing Feng#, Fangyuan Zhou#, Wenchao Lu, Dangge Wang, Tingting Wang, Cheng Luo, Hao Wang, Yaping Li, Haijun Yu*. Phospholipid-Mimic Oxaliplatin Prodrug Liposome for Treatment of Metastatic Triple Negative Breast Cancer. Biomater. Sci. 2017, 5, 1522-1525. (Emerging Investigators 2017 themed issue).

14.Fangyuan Zhou#, Bing Feng#, Tingting Wang, Qingshuo Meng, Dangge Wang, Jianfeng Zeng, Zhiwen Zhang, Siling Wang, Haijun Yu*, Yaping Li*. Programmed Multi-Responsive Vesicles for Enhanced Tumor Penetration and Combination Therapy of Triple-Negative Breast Cancer. Adv. Funct. Mater. 2017, 27, 1606530.

15.Qiang Feng#, Jianping Liu#, Xuanyu Li, Jiashu Sun,* Xinghua Shi, Haijun Yu,* Yaping Li, and Xingyu Jiang* One-Step Microfluidic Synthesis of Nanocomplex with Tunable Rigidity and Acid-Switchable Surface Charge for Overcoming Drug Resistance. Small. 2017, 13:1603109.

16.Dangge Wang,# Tingting Wang,# Jianping Liu, Haijun Yu,* Shi Jiao, Bing Feng, Fangyuan Zhou, Yuanlei Fu, Qi Yin, Pengcheng Zhang, Zhiwen Zhang, Zhaocai Zhou, Yaping Li,* Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade-Enhanced Cancer Photodynamic Immunotherapy. Nano Letters, 2016, 16, 5503-5513.

17.Bing Feng#, Fangyuan Zhou#, Zhiai Xu#, Tingting Wang, Dangge Wang, Jianping Liu, Qi Yin, Zhiwen Zhang, Haijun Yu*, Yaping Li*. Versatile Prodrug Nanoparticles for Acid-Triggered Precise Imaging and Organelle-Specific Combination Cancer Therapy. Adv. Funct. Mater. 2016, 26, 7431–7442.

18.Tingting Wang#, Dangge Wang#, Haijun Yu*, Mingwei Wang, Jianping Liu, Bing Feng, Fangyuan Zhou, Qi Yin, Zhiwen Zhang, Yaping Li* Intracellularly Acid-Switchable Multifunctional Micelles for Combinational Photo/ Chemotherapy of the Drug Resistant Tumor. ACS Nano. 2016, 10, 3496?3508.

19.Fangyuan Zhou#, Bing Feng#, Haijun Yu*, Dangge Wang, Tingting Wang, Jianping Liu, Qingshuo Meng, Siling Wang,*, Pengcheng Zhang, Zhiwen Zhang, Yaping Li*, Cisplatin Prodrug-Conjugated Gold Nanocluster: A Theranostic Platform for Treatment of Metastatic Breast Cancer. Theranostics. 2016, 6, 679-687.

20.Lijuan Zeng#, Lili Zou#, Haijun Yu#, Xinyu He, Haiqiang Cao, Zhiwen Zhang,* Qi Yin, Pengcheng Zhang, Wangwen Gu, Lingli Chen, and Yaping Li. Treatment of Malignant Brain Tumor by Tumor-Triggered Programmed Wormlike Micelles with Precise Targeting and Deep Penetration. Adv. Funct. Mater. 2016, 26, 4201– 4212.

21.Dangge Wang#, Tingting Wang#, Zhiai Xu, Haijun Yu*, Bing Feng, Junying Zhang, Chengyue Guo, Qi Yin, Zhiwen Zhang, Yaping Li* Cooperative Treatment of Metastatic Breast Cancer Using Host-Guest Nanoplatform Loading Docetaxel and siRNA. Small. 2016, 12, 488-498.

22.Haijun Yu*, Chengyue Guo, Xianzhi Chen, Bing Feng, Jianping Liu, Tingting Wang, Dangge Wang, Zhirui Cui, Qi Yin, Zhiwen Zhang, Yaping Li* Triple-Layered pH-Responsive Micelleplexes Loaded with siRNA and Cisplatin Prodrug for NF-Kappa B Targeted Treatment of Metastatic Breast Cancer. Theranostic, 2016, 6, 14-27.

23.Haijun Yu*#, Zhirui Cui#, Pengcheng Yu#, Chengyue Guo, Bing Feng, Tongying Jiang, Siling Wang, Qi Yin, Dafang Zhong, Xiangliang Yang, Zhiwen Zhang, Yaping Li*. pH and near-infrared light-responsive micelles with hyperthermia-triggered tumor penetration and cytoplasm drug release reverse doxorubicin resistance in breast cancer. Adv Funct Mater 2015, 25, 2489-2500. (Front Cover)(ESI highly cited)

24.Dangge Wang, Zhiai Xu, Haijun Yu*, Xianzhi Chen, Bing Feng, Zhirui Cui, Bin Lin,Qi Yin, Zhiwen Zhang, Chunying Chen, Jun Wang, Wen Zhang, Yaping Li. Treatment of metastatic breast cancer by combination of chemotherapy and photothermal ablation using doxorubicin-loaded DNA wrapped gold nanorods. Biomaterials. 2014, 35, 8374–8384.

25.Haijun Yu+, Junqiang Wang+*, Xuetao Shi, Dmitri V. Louzguine-Luzgin, Hongkai Wu*, John H. Perepezko* Ductile Biodegradable Mg-based Metallic Glasses with Excellent Biocompatibility. Adv Funct Mater, 2013, 23, 4793–4800.