1999年获中国药科大学药物化学专业理学博士学位，同年进入中科院上海药物所进行博士后研究，2001年9月博士后出站留所工作至今。现任中国科学院上海药物研究所研究员，博士生导师，新药研究国家重点实验室副主任。主要从事药物化学、化学生物学和药物设计研究。近年来紧扣“新药先导化合物的发现和优化”这条主线，构建了“有机合成新方法促进药物发现”新药研究技术体系，主要针对感染性疾病、肿瘤、代谢疾病以及老年性痴呆等重大疾病进行新药创制研究，发现了一批具有深入研究价值的先导化合物，部分化合物正在进行全面的临床前研究。围绕药物分子的优势骨架，系统开展了新的有机合成方法学研究，发展了一系列具有原始创新、高效的合成方法体系，构建了含有6000个分子的多样性“优势骨架杂环库”。其中在Chemical Reviews、Angewandte Chemie、Journal of Medicinal Chemistry、Chemistry & Biology、Organic Letters、Chemical Communications等杂志发表论文330余篇。申请专利58项，获得发明专利证书27项，实现技术转让6项，参与12本专著的编写。先后获得第四批国家“万人计划”科技创新领军人才、第十四届中国青年科技奖、全国优秀科技工作者、“国家自然科学”二等奖等多项奖励，获得国家杰出青年、全国“三八红旗手”等荣誉称号，其团队于2018年获得了科技部创新人才培养示范基地重点领域创新团队。

教育经历
09/01/1987-07/31/1991，中国药科大学化学制药系，理学学士
09/01/1993-07/31/1996，中国药科大学药物化学系，理学硕士
09/01/1996-07/31/1999，中国药科大学药物化学系，理学博士

工作经历
09/01/1991-08/31/1993，山东新华制药厂四车间，助理工程师
08/01/1999-08/31/2001，中国科学院上海药物研究所，博士后
02/01/2002-10/31/2002，美国 University of Texas Medical Branch 大学，访问科学家（Visiting Scientist）
01/01/2005-10/31/2005，美国 University of Texas Medical Branch 大学，访问科学家（Visiting Scientist）
09/01/2001-30/06/2006，中国科学院上海药物研究所，副研究员、硕士生导师
01/07/2006-至今，中国科学院上海药物研究所，研究员、博士生导师

1.Xuewu Liang, Jie Zang, Xiaoyang Li, Shuai Tang, Min Huang, Meiyu Geng, C. James Chou, Chunpu Li, Yichun Cao, Wenfang Xu, Hong Liu,* and Yingjie Zhang*. Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies. Journal of Medicinal Chemistry. 2019 , 62, 3898-3923.

2.Jianhui Zhou, Jian Li, Yazhou Li, Chenglin Wu, Guoxue He, Qiaolan Yang, Yu Zhou* and Hong Liu*.Direct Synthesis of 3-Acylindoles through Rhodium(III)-Catalyzed Annulation of N-Phenylamidines with α-Cl Ketones. Organic Letters. 2018, 20, 7645-7649.

3.Panfeng Peng, Huan Chen, Ya Zhu, Zhilong Wang, Jian Li, Rong-Hua Luo,Jiang Wang, Liang Chen, Liu-Meng Yang, Hualiang Jiang, Xin Xie,Beili Wu,*Yong-Tang Zheng,* and Hong Liu*.Structure -Based Design of 1-Heteroaryl-1,3-propanediamine Derivatives as a Novel Series of CC-Chemokine Receptor 5 Antagonists. Journal of Medicinal Chemistry. 2018, 61, 9621-9636.

4.Feifei Fang, Chunmei Zhang, Chaofan Zhou, Yazhou Li, Yu Zhou,* and Hong Liu*. Rh(III)-Catalyzed C?H Activation of Benzoylacetonitriles and Tandem Cyclization with Diazo Compounds to Substituted Benzo[de]chromenes. Organic letters. 2018, 20, 1720-1724.

5.Xiaowei Wu, Bao Wang, Yu Zhou,and Hong Liu*. Propargyl alcohols as one-carbon synthons: redox-neutral Rh (III)-catalyzed C-H bond activation for the synthesis of isoindolinones bearing a quaternary carbon. Organic Letters. 2017, 19, 1294-1297.

6.Xiaowei Wu, Bao Wang, Shengbin Zhou, Yu Zhou,* and Hong Liu*. Ruthenium-Catalyzed Redox-Neutral [4+1] Annulation of Benzamides and Propargyl Alcohols via C-H Bond Activation. ACS catalysis. 2017, 7, 2494-2499.

7.Wei Zhu, Hui Chen, Yulan Wang, Jiang Wang, Xia Peng, Xianjie Chen, Yinglei Gao, Yulong He, Jing Ai*, Meiyu Geng, Mingyue Zheng* and Hong Liu*. Design, Synthesis, and Pharmacological Evaluation of Novel Multi-substituted Pyridin-3-amine Derivatives as Multi-Targeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer. Journal of Medicinal Chemistry. 2017, 60, 6018-6035.

8.Yu Zhou, Jiang Wang, Zhanni Gu, Shuni Wang, Wei Zhu, Jose  Luis Acena,* Vadim A. Soloshonok,* Kunisuke Izawa,* and Hong Liu*. Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II?III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas. Chemical Reviews. 2016, 116, 422-518.

9.Fei Zhao, Jing Li, Ying Chen, Yanxin Tian, Chenglin Wu, Yanan Xie, Yu Zhou, Jiang Wang, Xin Xie,* and Hong Liu*. Design, Synthesis, and Biological Evaluation of Indoline and Indole Derivatives as Potent and Selective α1A-Adrenoceptor Antagonists. Journal of Medicinal Chemistry. 2016, 59, 3826?3839.

10.Panfeng Peng, Jiang Wang, Hualiang Jiang,and Hong Liu*. Rhodium(III)-Catalyzed Site-Selective C-H Alkylation and Arylation of Pyridones Using Organoboron Reagents. Organic Letters. 2016, 18, 5376?5379.

11.Diliang Guo, Jing Li, Henry Lin, Yu Zhou, Ying Chen, Fei Zhao, Haifeng Sun, Dan Zhang, Honglin Li, Brian K. Shoichet, Lei Shan, Weidong Zhang, Xin Xie,* Hualiang Jiang,* Hong Liu*. Design, Synthesis and Biological Evaluation of Novel Tetrahydroprotoberberine Derivatives (THPBs) as Selective α1A-Adrenoceptor Antagonists. Journal of Medicinal Chemistry. 2016, 59, 9489?9502.

12.Xiaowei Wu, Dengyou Zhang, Shengbin Zhou, Feng Gao and Hong Liu*. Site-specific indolation of proline-based peptides via copper(II)-catalyzed oxidative coupling of tertiary amine N-oxides. Chemical Communications. 2015, 51, 12571–12573.

13.Yong Nian, Jiang Wang, Shengbin Zhou, Shuni Wang, Hiroki Moriwaki, Aki Kawashima, Vadim A. Soloshonok,* and Hong Liu*. Recyclable Ligands for the Non-Enzymatic Dynamic Kinetic Resolution of Challenging α-Amino Acids. Angewandte Chemie International Edition. 2015, 54, 12918–12922.

14.Dengyou Zhang, Feng Gao, Yong Nian, Yu Zhou, Hualiang Jiang, and Hong Liu*. Palladium-Catalyzed Picolinamide-Directed Coupling of C(sp2)-H and C(sp2)-H: a Straightforward Approach to Quinolinone and Pyridone Scaffolds. Chemical Communications. 2015, 51, 7509 – 7511.

15.Shengbin Zhou, Jiang Wang, Xia Chen, José Luis Acea Vadim A. Soloshonok,* and Hong Liu*. Chemical Kinetic Resolution of Unprotected b-Substituted-b-Amino Acids Using Recyclable Chiral Ligands. Angewandte Chemie International Edition. 2014, 53, 7883-7886.

16.Jiang Wang, María Sanchez-Rosello, Jose Luis Acen?a, Carlos del Pozo, Alexander E. Sorochinsky, Santos Fustero*, Vadim A. Soloshonok,* Hong Liu*. Fluorine in Pharmaceutical Industry; Fluorinated Drugs Introduced to the Market in the Last Decade. Chemical Reviews. 2014,114, 2432?2506.

17.Enguang Feng, Woo-Jin Shin, Xuelian Zhu, Jian Li, Deju Ye, Jiang Wang, Jian-Ping Zuo, Kyoung Tai No, Mingyue Zheng, Weiliang Zhu, * Wei Tang, * Baik-Lin Seong,* Hualiang Jiang, and Hong Liu*. Structure-Based Design, Synthesis of C-1 and C-4 modified analogs of zanamivir as neuraminidase inhibitors. Journal of Medicinal Chemistry . 2013, 56, 671-684.

18.Shengtao Xu, Yu Zhou, Jinyi Xu*, Hualiang Jiang, and Hong Liu*. Gold-catalyzed Michael Addition/Intramolecular Annulation Cascade: an Effective Pathway for the Chemoselective- and Regioselective Synthesis of Tetracyclic Indole Derivatives in Water. Green Chemistry. 2013,15,718-726.

19.Xianjie Chen , Hui Chen, Xun Ji, Hualiang Jiang*, Zhu-Jun Yao, and Hong Liu*. Asymmetric One-Pot Sequential Mannich/Hydroamination Reaction by Organo- and Gold Catalysts: Synthesis of Spiro [pyrrolidin-3, 2′-oxindole] Derivatives. Organic Letters. 2013,15,1846-1849.

20.Dengyou Zhang, Haifeng Sun, Lei Zhang, Yu Zhou, Chunpu Li, Hualiang Jiang, Kaixian Chen, and Hong Liu.* An Expedient Pd/DBU Mediated Cyanation of Aryl/Heteroaryl Bromides With K4[Fe(CN)6]. Chemical Communications. 2012, 48, 2909–2911.

21.Diliang Guo, Tao Chen, Deju Ye, Jinyi Xu, Hualiang Jiang, Kaixian Chen, Hui Wang*, and Hong Liu*. Cell-Permeable Iminocoumarine-Based Fluorescent Dyes for Mitochondria. Organic Letters. 2011, 13, 2884-2887.

22.Xu Zhang, Yu Zhou, Hengshuai Wang, Diliang Guo, Deju Ye, Yungen Xu, Hualiang Jiang and Hong Liu*. Silver-catalyzed intramolecular hydroamination of alkynes in aqueous media: efficient and regioselective synthesis for fused benzimidazoles. Green Chemistry. 2011, 3, 397-405.

23.Yu Zhou, Chunyi Jiang, Yaping Zhang, Zhongjie Liang, Wenfeng Liu, Liefeng Wang, Cheng Luo, Tingting Zhong, Yi Sun, Linxiang Zhao, Xin Xie, Hualiang Jiang, Naiming Zhou,* Dongxiang Liu* and Hong Liu*. Structural Optimization and Biological Evaluation of Substituted Bisphenol A Derivatives as β-Amyloid Peptide Aggregation Inhibitors. Journal of Medicinal Chemistry. 2010, 53, 5449-5466.

24.Yu Zhou,Yun Zhai, Jian Li, Deju Ye, Hualiang Jiang and Hong Liu.* Metal-free Tandem Reaction in Water: An Efficient and Regioselective Synthesis of 3-Hydroxyisoindolin-1-ones. Green Chemistry. 2010, 12, 1397-1404.

25.He Huang, Qin Chen，Xin Ku, Linghua Meng*, Liping Lin, Xiang Wang, Caihua Zhu, Yi Wang, Zhi Chen, Ming Li, Hualiang Jiang, Kaixian Chen, Jian Ding , Hong Liu.* A series of α-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIα catalytic activity. Journal of Medicinal Chemistry. 2010, 53, 3048-3064.