张传瑞，研究员、课题组长。2008年博士毕业于中国科学院上海药物研究所，师从岳建民院士，同年留所工作至2011年，分别担任助理研究员、副研究员。其后，分别在美国亚利桑那大学和密歇根州立大学进行博士后研究，2016年加入重庆大学药学院工作，任研究员\/课题组长。2022年加入中科院上海药物研究所\/中科环渤海（烟台）药物高等研究院。长期从事天然药物与中药现代化研究，已在国际知名期刊Org. Lett.、J. Nat. Prod.、Food Chem.、J. Agric. Food Chem<\/i>.等以第一或通讯作者发表论文约40篇。<\/div>\n
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教育经历：<\/b><\/div>\n
1.2003.09-2008.07，中国科学院上海药物研究所，药物化学，博士，导师：岳建民院士<\/div>\n
2.1999.09-2003.07，北京师范大学化学学院，应用化学，学士，导师：刘伯里院士<\/div>\n ","yjfx":"
1. 药用植物或真菌中新颖结构和活性化合物的发现、先导化合物的构效研究和结构优化以及新药研发<\/div>\n
2. 药食两用植物或功能性食品中活性物质的发现、作用机制研究以及保健品开发<\/div>\n
3. 中药药效物质基础和药理作用机制以及中药现代化<\/div>","dblz":"
1.Yan Wen#, Li Rao#, Fan Xu, Yang Li, Yong-Xin Luo, Xu Gong, Ri-Hui Wu, Chuan-Rui Zhang<\/b>*, Li-She Gan*. Six pairs of phenylpropanoid enantiomers from Cinnamomum mollifolium. Phytochemistry<\/i> 2022, 203, 113348.<\/font><\/div>\n
2.Li Rao#, Yu Su#, Qian He#, Jia Ye, Yu Liu, Yue Fan, Feng Hu, Zhen Zhou, Li-She Gan, Yonghui Zhang*, Chuan-Rui Zhang<\/b>*. Geranylated or prenylated flavonoids from Cajanus volubilis. Chinese Journal of Natural Medicines<\/i> 2022, 20(0): 1？6. doi: 10.1016\/S1875-5364(22)60215-2.<\/font><\/div>\n
3.Qian He#, Simin Li#, Yue Fan, Yu Liu, Yu Su, Zhen Zhou, Yi-Nan Zhang, Guo-Li Li*, Li Rao*, Chuan-Rui Zhang<\/b>*. Complex flavanones from Cryptocarya metcalfiana and structural revision of oboflavanone A. Journal of Natural Products<\/i> 2022, 85, 1617？1625.<\/font><\/div>\n
4.Yu Liu, Yun-Xia You, Li Rao, Qian He, Yu Su, Yue Fan, Yizhou Li, You-Kai Xu, Chuan-Rui Zhang<\/b>*. Geranyl phenyl ethers from Illicium micranthum and their anti-HBV activity. Chinese Journal of Natural Medicines<\/i> 2022, 20, 139？147.<\/font><\/div>\n
5.Qian He, Yue Fan, Yu Liu, Li Rao, Yun-Xia You, Yu Su, Zhen Zhou, You-Kai Xu, Chuan-Rui Zhang<\/b>*. Cryptoyunnanones A？H, complex flavanones from Cryptocarya yunnanensis. Journal of Natural Products<\/i> 2021, 84, 2209？2216.<\/font><\/div>\n
6.Li Rao, Yao Li, Qian He, Yu Liu, Yu Su, Yun-Xia You, Yue Fan, Bin Lin, Yi-Nan Zhang, Chuan-Rui Zhang<\/b>*. Iridoid constituents of Viburnum brachybotryum. Journal of Natural Products<\/i> 2021, 84, 1915？1923.<\/font><\/div>\n
7.Li Rao, Yun-Xia You, Yu Su, Yue Fan, Yu Liu, Qian He, Yi Chen, Jie Meng, Lin Hu, Yizhou Li, You-Kai Xu, Bin Lin, Chuan-Rui Zhang*<\/b>. Lignans and neolignans with antioxidant and human cancer cell proliferation inhibitory activities from Cinnamomum bejolghota confirm its functional food property. Journal of Agricultural and Food Chemistry<\/i> 2020, 68, 8825？8835.<\/font><\/div>\n
8.Hong-Yan Xu#, Ji-Hua Ren#, Yu Su#, Fang Ren, Yu-Jiao Zhou, Hui Jiang, Sheng-Tao Cheng, Chuan-Rui Zhang<\/b>*, Juan Chen*. Anti-hepatitis B virus activity of swertisin isolated from Iris tectorum Maxim. Journal of Ethnopharmacology<\/i> 2020, 257, 112787. <\/font><\/div>\n
9.Wei Li, Li Rao, Yu Liu, Qian He, Yue Fan, Yun-Xia You, Yu Su, Feng Hu, You-Kai Xu, Bin Lin, Sheng Yin, Chuan-Rui Zhang<\/b>*. (±)-Meliviticines A and B: rearranged prenylated acetophenone derivatives from Melicope viticina and their antimicrobial activity. Bioorganic Chemistry<\/i> 2019, 90, 103099.<\/font><\/div>\n
10.Chuan-Rui Zhang<\/b>, Wajid Khan, Jehan Bakht, Muraleedharan G. Nair*. New antiinflammatory sucrose esters in the natural sticky coating of tomatillo (Physalis philadelphica), an important culinary fruit. Food Chemistry<\/i> 2016, 196, 726-732. <\/font><\/div>\n
11.Chuan-Rui Zhang<\/b>, Amila A. Dissanayake, Kudret Kevsero？lu, Muraleedharan G. Nair*. Evaluation of coriander spice as a functional food by using in vitro bioassays. Food Chemistry<\/i> 2015, 167, 24-29. <\/font><\/div>\n
12.Chuan-Rui Zhang<\/b>, Amila A. Dissanayake, Muraleedharan G. Nair*. Functional food property of honey locust (Gleditsia triacanthos) flowers. Journal of Functional Foods<\/i> 2015, 18, 266-274. <\/font><\/div>\n
13.Chuan-Rui Zhang<\/b>, Saleh A. Aldosari, Polana S. P. V. Vidyasagar, Karun M. Nair, Muraleedharan G. Nair*. Antioxidant and anti-inflammatory assays confirm bioactive compounds in ajwa date fruit. Journal of Agricultural and Food Chemistry <\/i>2013, 61, 5834-5840.<\/font><\/div>\n
14.Chuan-Rui Zhang<\/b>#, Cheng-Qi Fan#, Shi-Hui Dong, Hong-Bing Liu, Wen-Bin Zhou, Yan Wu, Jian-Min Yue*. Angustimine and angustifolimine, two new alkaloids from Daphniphyllum angustifolium. Organic Letters <\/i>2011, 13, 2440-2443. (#同等贡献)<\/font><\/div>\n
15.Chuan-Rui Zhang<\/b>, Hong-Bing Liu, Shi-Hui Dong, Jian-Yong Zhu, Yan Wu, Jian-Min Yue*. Calycinumines A and B, two novel alkaloids from Daphniphyllum calycinum. Organic Letters <\/i>2009, 11, 4692-4695. <\/font><\/div>\n
16.Chuan-Rui Zhang<\/b>, Hong-Bing Liu, Shi-Hui Dong, Jian-Yong Zhu, Yan Wu, Jian-Min Yue*. Alkaloids from the leaves of Daphniphyllum subverticillatum. Journal of Natural Products<\/i> 2009, 72, 1669-1672. <\/font><\/div>\n
17.Chuan-Rui Zhang<\/b>, Sheng-Ping Yang, Yan Wu, Jian-Min Yue*. Alkaloids from the twigs of Daphniphyllum calycinum. Journal of Natural Products<\/i> 2008, 71, 1663-1668. <\/font><\/div>\n
18.Chuan-Rui Zhang<\/b>, Cheng-Qi Fan, Li Zhang, Sheng-Ping Yang, Yan Wu, Yang Lu, Jian-Min Yue*. Chuktabrins A and B, two novel limonoids from the twigs and leaves of Chukrasia tabularis. Organic Letters<\/i> 2008, 10, 3183-3186.<\/font><\/div>\n
19.Chuan-Rui Zhang<\/b>, Sheng-Ping Yang, Shang-Gao Liao, Cheng-Qi Fan, Yan Wu, Jian-Min Yue*. Chuktabularins A？D, four new limonoids with unprecedented carbon skeletons from the stem bark of Chukrasia tabularis. Organic Letters <\/i>2007, 9, 3383-3386. <\/font><\/div>\n
20.Chuan-Rui Zhang<\/b>, Sheng-Ping Yang, Qiao Zhu, Shang-Gao Liao, Yan Wu, Jian-Min Yue. Nortriterpenoids from Chukrasia tabularis var. velutina. Journal of Natural Products<\/i> 2007, 70, 1616-1619.<\/font><\/div>\n <\/font>","jyjl":"","gzjl":"
1.2022.10-至今，中科院上海药物研究所\/中科环渤海（烟台）药物高等研究院，课题组长、研究员<\/div>\n
2.2016.07-2022.10，重庆大学药学院，课题组长、研究员<\/div>\n
3.2012.01-2015.12，密歇根州立大学，博士后<\/div>\n4.2011.01-2015.12，亚利桑那大学，博士后 ","ktxm":"
1. 国家自然科学基金面上项目，厚壳桂属特征性成分及其抑制4E-BP1磷酸化的抗肿瘤作用研究，主持，2022.01-2025.12<\/div>\n
2. 国家自然科学基金重点项目，天然产物对雌激素合成和代谢调控机制的研究，课题主持人（项目负责人：中国科学院成都生物研究所张国林研究员），结题<\/div>\n
3. 国家自然科学基金青年科学基金，两种桃花心木属植物中生物活性成分的研究，主持，结题<\/div>\n
4. 重庆市自然科学基金面上项目，中药小花八角中抗乙肝病毒活性先导化合物的发现及其药理作用机制研究，主持，结题<\/div>\n ","ryhj":"
1. 2010年上海市自然科学一等奖(岳建民、杨升平、丁健、张传瑞、尹胜)<\/div>\n
2. 2009年中国药学会科学技术奖二等奖(岳建民、杨升平、丁健、张传瑞、尹胜)<\/div>\n
3. 2009年上海药物研究所优秀青年科技工作者<\/div>\n
4. 2008年上海药学科技奖一等奖(岳建民、杨升平、丁健、张传瑞、尹胜)<\/div>\n5. 2008中国科学院朱李月华优秀博士生奖学金 ","xpwj":"http://sourcedb.simm.cas.cn/zw/gb2020/yjzz/202212/P020221228363621873067.jpg","kycg":"
从事天然药物与中药现代化研究，迄今已完成50多种传统药用植物或药食两用植物的系统研究，得到1200多个单体化合物，其中新化合物400多个，包括50多个新骨架，活性化合物100多个；阐明了多种药用植物或药食两用植物的药效物质基础和作用机制。迄今已在天然药物或食品领域知名期刊Org. Lett.、J. Nat. Prod.、Food Chem.、J. Agric. Food Chem.等以第一或通讯作者发表论文60多篇。<\/div>\n ","shrz":"","puburl":"http://sourcedb.simm.cas.cn/zw/gb2020/yjzz/202212/t20221228_6591344.json"});