cas_call({"xm":"管栋梁","xb":"男","zc":"研究员","xl":"博士","dh":"","cz":"","dzyj":"guandongliang@simm.ac.cn","grzy":"","zjlb":"研究员","zw":"课题组长","txdz":"烟台市高新区滨海东路198号","grjj":"
2019年博士毕业于中科院上海药物研究所,而后于2019年8月-2022年11月分别在加州大学圣地亚哥和RTI国际进行药物化学博士后的研究,并于2022年12月加入中国科学院上海药物研究所担任青年课题组长,自2024年1月起担任课题组长。<\/div>\n
主要从事合成药物化学的研究,包括抗感染领域新药开发以及小分子GPCR相关靶点调节剂的开发。已在国际学术期刊上发表18篇SCI文章,其中以第一作者(含共同)\/通讯作者身份发表7篇,包括
Angew. Chem. Int. Ed., J. Med. Chem., Eur. J. Med. Chem.<\/i> 等。以主要申请人身份申请中国专利2项,美国专利1项,获授权1项。<\/div>\n <\/div>\n
教育经历:<\/b><\/div>\n <\/div>\n
2014.09-2019.07 中国科学院上海药物研究所,药物化学,硕博<\/div>\n
2010.09-2014.07 烟台大学药学院, 药学,本科<\/div>\n
<\/div>","yjfx":"抗感染领域合成药物化学,主要针对高风险耐药性微生物开发新型有效的候选药物分子","dblz":"
1. Dongliang Guan*,<\/b> Jian Li, Feifei Chen, Jiaqi Li, Xiaolei Bian, Xinxin Feng*, Lefu Lan*, Wei Huang*. A facile and selective derivatization approach on kynurenine-NH2 in daptomycin, leading to the discovery of hexakynomycin to combat multidrug-resistant Gram-positive pathogens especially daptomycin-resistant bacteria. European Journal of Medicinal Chemistry<\/i>, 2023, 259: 115638.<\/font><\/div>\n2.Dongliang Guan<\/b>, Md Toufiqur Rahman, Elaine A. Gay, Vineetha Vasukuttan, Kelly M. Mathews, Ann M. Decker, Alexander H. Williams, Chang-Guo Zhan, and Chunyang Jin*. Indole-Containing Amidinohydrazones as Nonpeptide, Dual RXFP3\/4 Agonists: Synthesis, Structure–Activity Relationship, and Molecular Modeling Studies. Journal of Medicinal Chemistry<\/i>, 2021, 64(24), 17866-17886.<\/font><\/div>\n3.Jian Li, Dongliang Guan<\/b> (共一), Feifei Chen, Weiwei Shi, Lefu Lan*, Wei Huang*. Total and Semisyntheses of Polymyxin Analogues with 2-Thr or 10-Thr Modifications to Decipher the Structure–Activity Relationship and Improve the Antibacterial Activity. Journal of Medicinal Chemistry,<\/i> 2021, 64(9), 5746-5765.<\/font><\/div>\n4.Dongliang Guan<\/b>, Feifei Chen, Yunguang Qiu, Bofeng Jiang, Likun Gong, Lefu Lan*, Wei Huang*. Sulfonium, an underestimated moiety for structural modification, alters antibacterial profile of vancomycin against multidrug-resistant bacteria. Angew. Chem., Int. Ed<\/i>. 2019, 58 (20), 6678-6682.<\/font><\/div>\n5.Dongliang Guan<\/b>, Feifei Chen, Lun Xiong, Feng Tang, Faridoon, Yunguang Qiu, Naixia Zhang, Likun Gong, Jian Li, Lefu Lan*, and Wei Huang*, Extra Sugar on Vancomycin: New Analogues for Combating Multidrug-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci. Journal of Medicinal Chemistry<\/i> 2018, 61 (1), 286-304.<\/font><\/div>\n <\/div>","jyjl":"","gzjl":"
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2024.01-至今 中国科学院上海药物研究所,研究员、课题组长<\/div>\n
2022.12-2023.12 中国科学院上海药物研究所, 副研究员、青年课题组长<\/div>\n
2020.11-2022.11 美国RTI International, 博士后<\/div>\n
2019.08-2020.11 美国UC San Diego, 博士后<\/div>\n<\/div>\n<\/div>\n ","ktxm":"国家自然科学基金青年科学基金项目(82304272) 资助经费:30万元 执行年限:2024-2026 ","ryhj":"
2023 高等学校科学研究优秀成果奖(科学技术) 自然科学奖 一等奖;<\/div>\n
2019 上海市优秀毕业生;<\/div>\n
2019 中国科学院优秀共青团员;<\/div>\n
2019 中国科学院地奥一等奖学金;<\/div>\n
2019 上海药物所启健二等奖学金;<\/div>\n
2018 博士研究生国家奖学金;<\/div>\n
<\/div>","xpwj":"http://sourcedb.simm.cas.cn/zw/gb2020/yjzz/202212/P020221216688398070774.jpg","kycg":"我们采用了糖修饰策略与硫鎓修饰策略有效解决了细菌耐药问题,开发了1个抗耐药菌候选药物-新型糖肽类抗生素SM-V-61,已经实现了项目转化,正在进行IND的申报。","shrz":" ","puburl":"http://sourcedb.simm.cas.cn/zw/gb2020/yjzz/202212/t20221216_6585509.json"});