cas_call({"xm":"韩海浩","xb":"男","zc":"副研究员","xl":"博士","dh":"","cz":"","dzyj":"hanhaihao@simm.ac.cn","grzy":"","zjlb":"研究员","zw":"青年课题组长","txdz":"烟台市高新区滨海东路198号","grjj":"<div>韩海浩，中国科学院上海药物研究所\/中科环渤海（烟台）药物高等研究院副研究员，青年课题组长，中国化学会会员。2020年6月于华东理工大学获工学博士学位，2020年7月-2022年6月于华东理工大学化学博士后科研流动站从事博士后研究工作。迄今已发表SCI论文30余篇，其中以共同通讯或第一（含共一）作者在<font face=\"Arial\"><i>J. Am. Chem. Soc., Chem. Sci., Theranostics, Sci. Bull., Chem. Soc. Rev., Coord. Chem. Rev<\/i><\/font>.等国内外知名期刊发表论文19篇，总引用&gt; 1400，h指数15。曾获山东省优秀毕业生、博士研究生国家奖学金、高水平期刊论文奖、第五届世界诊疗大会旅行奖等奖励。作为项目负责人，主持了国家自然科学基金青年科学基金，中国博士后科学基金第68批面上资助，以及华东理工大学首届“张江树”优博培育计划等项目。近期，受邀担任《Frontier in Chemistry》国际期刊评审编辑（Review Editor），同时长期担任英国皇家化学会国际期刊同行评议员。<\/div>\n<div>&nbsp;<\/div>\n<div>&nbsp;<\/div>\n<div><b>教育经历：<\/b>　<\/div>\n<div>1. 2015.09-2020.06，华东理工大学，应用化学，硕博<\/div>\n2. 2011.09-2015.06，山东理工大学，应用化学，本科&nbsp;","yjfx":"<div>1. 恶性肿瘤和代谢性疾病演进过程中生物大分子动态修饰的化学探测；<\/div>\n<div>2. 恶性肿瘤和代谢性疾病的光学、多模态成像与治疗一体化新材料创制；<\/div>\n3. 人类重大疾病的糖靶向药研发与临床转化。&nbsp;","dblz":"<div><font face=\"Arial\" style=\"line-height: 150%;\">1.<b>Hai-Hao Han<\/b>, He Tian Jr., Yi Zang, Adam C Sedgwick, Jia Li*, Jonathan L Sessler*, Xiao-Peng He*, Tony D. James*. Small-molecule fluorescence-based probes for interrogating major organ diseases. <i>Chemical Society Reviews<\/i>. 2021, 50: (17), 9391-9429.&nbsp;<\/font><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\">2.<b>Hai-Hao Han<\/b><sup>#<\/sup>, Adam C Sedgwick<sup>#<\/sup>, Ying Shang<sup>#<\/sup>, Na Li, Tingting Liu, Bo-Han Li, Kunqian Yu, Yi Zang, James T Brewster, Maria L Odyniec, Maria Weber, Steven D Bull, Jia Li*, Jonathan L Sessler*, Tony D James*, Xiao-Peng He*, He Tian. Protein encapsulation: a new approach for improving the capability of small-molecule fluorogenic probes. <i>Chemical Scienc<\/i>e. 2020, 11, 1107-1113<\/font><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\">3.<b>Hai-Hao Han<\/b><\/font><span style=\"font-family: Arial;\"><sup>#<\/sup><\/span><span style=\"font-family: Arial; font-size: 12pt;\">, Yu-Jiao Qiu<\/span><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-size: 12pt; font-family: Arial;\">, Yuan-Yuan Shi<\/span><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-size: 12pt; font-family: Arial;\">, Wen Wen, Xiao-Peng He*, Li-Wei Dong*, Ye-Xiong Tan*, Yi-Tao Long, He Tian, Hong-Yang Wang*. Glypican-3-targeted precision diagnosis of hepatocellular carcinoma on clinical sections with a supramolecular 2D imaging probe.<\/span><i style=\"font-size: 12pt; font-family: Arial;\"> Theranostics.<\/i><span style=\"font-size: 12pt; font-family: Arial;\"> 2018, 8: (12), 3268.&nbsp;<\/span><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\">4.Xianzhi Chai<\/font><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-family: Arial; font-size: 12pt;\">, <\/span><b style=\"font-family: Arial; font-size: 12pt;\">Hai-Hao Han<\/b><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-size: 12pt; font-family: Arial;\">, Adam C. Sedgwick<\/span><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-size: 12pt; font-family: Arial;\">, Na Li, Yi Zang, Tony D. James, Junji Zhang*, Xi-Le Hu, Yang Yu, Yao Li, Yan Wang, Jia Li*, Xiao-Peng He*, He Tian. Photochromic Fluorescent Probe Strategy for the Super-resolution Imaging of Biologically Important Biomarkers. <\/span><i style=\"font-size: 12pt; font-family: Arial;\">Journal of the American Chemical Society<\/i><span style=\"font-size: 12pt; font-family: Arial;\">. 2020, 142: (42), 18005-18013.&nbsp;<\/span><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\">5.Youxin Fu<\/font><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-family: Arial; font-size: 12pt;\">, <\/span><b style=\"font-family: Arial; font-size: 12pt;\">Hai-Hao Han<\/b><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-size: 12pt; font-family: Arial;\">, Junji Zhang*, Xiao-Peng He*, Ben L Feringa, He Tian*. Photocontrolled fluorescence “double-check” bioimaging enabled by a glycoprobe–protein hybrid. <\/span><i style=\"font-size: 12pt; font-family: Arial;\">Journal of the American Chemical Society<\/i><span style=\"font-size: 12pt; font-family: Arial;\">. 2018, 140: (28), 8671-8674.&nbsp;<\/span><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\">6.<b>Hai-Hao Han<\/b>, Chang Zheng Wang, Yi Zang, Jia Li*, Tony D James, Xiao-Peng He*. Supramolecular core–glycoshell polythiophene nanodots for targeted imaging and photodynamic therapy. <i>Chemical Communications.<\/i> 2017, 53: (70), 9793-9796.&nbsp;<\/font><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\">7.Hai-Na Xie<\/font><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-family: Arial; font-size: 12pt;\">, Yu-Yuan Chen<\/span><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-size: 12pt; font-family: Arial;\">, Guo-Biao Zhu, <\/span><b style=\"font-size: 12pt; font-family: Arial;\">Hai-Hao Han<\/b><span style=\"font-size: 12pt; font-family: Arial;\">*, Xile Hu, Zhi-Qiang Pan, Yi Zang, Donghao Xie*, Xiao-Peng He, Jia Li*, Tony D. James*. Targeted delivery of maytansine to liver cancer cells via galactose-modified supramolecular two-dimensional glycomaterial. <\/span><i style=\"font-size: 12pt; font-family: Arial;\">Chemical Communications<\/i><span style=\"font-size: 12pt; font-family: Arial;\">. 2022, 58 (32), 5029-5032.&nbsp;<\/span><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\">8.Luling Wu<\/font><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-family: Arial; font-size: 12pt;\">, Jihong Liu<\/span><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-size: 12pt; font-family: Arial;\">, Xue Tian<\/span><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-size: 12pt; font-family: Arial;\">, Robin R. Groleau, Beidou Feng, Yonggang Yang, Adam C. Sedgwick, <\/span><b style=\"font-size: 12pt; font-family: Arial;\">Hai-Hao Han*<\/b><span style=\"font-size: 12pt; font-family: Arial;\">, Yang Wang, Han-Min Wang, Fang Huang, Steven D. Bull, Hua Zhang*, Chusen Huang*, Yi Zang, Jia Li, Xiao-Peng He, Ping Li*, Bo Tang, Tony D. James*, Jonathan L. Sessler*. Dual-Channel Fluorescent Probe for the Simultaneous Monitoring of Peroxynitrite and Adenosine-5\'-triphosphate in Cellular Applications. <\/span><i style=\"font-size: 12pt; font-family: Arial;\">Journal of the American Chemical Society<\/i><span style=\"font-size: 12pt; font-family: Arial;\">. 2022, 144: (1), 174-183.&nbsp;<\/span><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\">9.Adam C Sedgwick<\/font><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-family: Arial; font-size: 12pt;\">, <\/span><b style=\"font-family: Arial; font-size: 12pt;\">Hai-Hao Han<\/b><span style=\"font-family: Arial;\"><sup>#<\/sup><\/span><span style=\"font-family: Arial; font-size: 12pt;\">,<\/span><span style=\"font-family: Arial; font-size: 12pt;\">&nbsp;<\/span><span style=\"font-size: 12pt; font-family: Arial;\">Jordan E Gardiner, Steven D Bull*, Xiao-Peng He*, Tony D James*. The development of a novel AND logic based fluorescence probe for the detection of peroxynitrite and GSH. <\/span><i style=\"font-size: 12pt; font-family: Arial;\">Chemical Science<\/i><span style=\"font-size: 12pt; font-family: Arial;\">. 2018, 9: (15), 3672-3676.&nbsp;<\/span><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\">10.Changzheng Wang<\/font><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-family: Arial; font-size: 12pt;\">, <\/span><b style=\"font-family: Arial; font-size: 12pt;\">Hai-Hao Han<\/b><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-size: 12pt; font-family: Arial;\">, Xinying Tang, Dongming Zhou*, Changfeng Wu, Guorong Chen, Xiao-Peng He*, He Tian. Sialylglycan-assembled supra-dots for ratiometric probing and blocking of human-infecting influenza viruses. <\/span><i style=\"font-size: 12pt; font-family: Arial;\">ACS Applied Materials &amp; Interfaces.<\/i><span style=\"font-size: 12pt; font-family: Arial;\"> 2017, 9: (30), 25164-25170.&nbsp;<\/span><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\">11.Wei-Tao Dou<\/font><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-family: Arial; font-size: 12pt;\">, <\/span><b style=\"font-family: Arial; font-size: 12pt;\">Hai-Hao Han<\/b><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-size: 12pt; font-family: Arial;\">, Adam C.Sedgwick, Guo-Biao Zhu, Yi Zang, Xin-Rong Yang*, Juyoung Yoon*, Tony D. James*, Jia Li*, Xiao-Peng He*. Fluorescent probes for the detection of disease-associated biomarkers.<\/span><i style=\"font-size: 12pt; font-family: Arial;\"> Science Bulletin<\/i><span style=\"font-size: 12pt; font-family: Arial;\">. 2022, 67, 853-878.&nbsp;<\/span><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\">12.Maria Weber<\/font><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-family: Arial; font-size: 12pt;\">, <\/span><b style=\"font-family: Arial; font-size: 12pt;\">Hai-Hao Han<\/b><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-size: 12pt; font-family: Arial;\">, Bo-Han Li<\/span><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-size: 12pt; font-family: Arial;\">, Maria L. Odyniec, Charlotte E. F. Jarman, Yi Zang, Steven D. Bull, Amanda B. Mackenzie, Adam C. Sedgwick*, Jia Li*, Xiao-Peng He*, Tony D. James*. Pinkment: a synthetic platform for the development of fluorescent probes for diagnostic and theranostic applications.<\/span><i style=\"font-size: 12pt; font-family: Arial;\"> Chemical Science<\/i><span style=\"font-size: 12pt; font-family: Arial;\">. 2020, 11: (32), 8567-8571.&nbsp;<\/span><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\">13.Lei Dong<\/font><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-family: Arial; font-size: 12pt;\">, Min-Yu Zhang<\/span><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-size: 12pt; font-family: Arial;\">, <\/span><b style=\"font-size: 12pt; font-family: Arial;\">Hai-Hao Han<\/b><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-size: 12pt; font-family: Arial;\">, Yi Zang, Guo-Rong Chen, Jia Li*, Xiao-Peng He*, Sébastien Vidal*. A general strategy to the intracellular sensing of glycosidases using AIE-based glycoclusters. <\/span><i style=\"font-size: 12pt; font-family: Arial;\">Chemical Science<\/i><span style=\"font-size: 12pt; font-family: Arial;\">. 2022, 13: (1), 247-256.&nbsp;<\/span><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\">14.He Tian Jr.<\/font><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-family: Arial; font-size: 12pt;\">, Adam C. Sedgwick<\/span><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-size: 12pt; font-family: Arial;\">, <\/span><b style=\"font-size: 12pt; font-family: Arial;\">Hai-Hao Han<\/b><span style=\"font-family: Arial; font-size: 12pt;\"><sup>#<\/sup><\/span><span style=\"font-size: 12pt; font-family: Arial;\">, Sajal Sen, Guo-Rong Chen, Yi Zang, Jonathan L. Sessler*, Tony D. James*, Jia Li*, Xiao-Peng He*. Fluorescent probes for the imaging of lipid droplets in live cells. <\/span><i style=\"font-size: 12pt; font-family: Arial;\">Coordination Chemistry Reviews<\/i><span style=\"font-size: 12pt; font-family: Arial;\">. 2021, 427, 213577.&nbsp;<\/span><\/div>\n<font face=\"Arial\" style=\"line-height: 150%;\">&nbsp;<\/font>","jyjl":"","gzjl":"<li class=\"timeline-item\">\n<div class=\"timeline-item-content\"><label>2022.07-至今<\/label>\n<div>中国科学院上海药物研究所\/中科环渤海（烟台）药物高等研究院，青年课题组长、副研究员<\/div>\n<\/div>\n<div class=\"timeline-item-tail\">&nbsp;<\/div>\n<div class=\"timeline-item-head\">&nbsp;<\/div>\n<div class=\"timeline-item-right\">&nbsp;<\/div>\n<\/li>\n<li class=\"timeline-item\">\n<div class=\"timeline-item-content\"><label>2020.07-2022.06 <\/label>\n<div>华东理工大学，化学博士后科研流动站，博士后<\/div>\n<\/div>\n<div class=\"timeline-item-tail\">&nbsp;<\/div>\n<div class=\"timeline-item-head\">&nbsp;<\/div>\n<div class=\"timeline-item-right\">&nbsp;<\/div>\n<\/li>","ktxm":"<li class=\"timeline-item\">\n<div class=\"timeline-item-content\"><label>2022\/01-2024\/12<\/label>\n<div>国家自然科学基金青年科学基金项目，在研、项目负责人。<\/div>\n<\/div>\n<div class=\"timeline-item-tail\">&nbsp;<\/div>\n<div class=\"timeline-item-head\">&nbsp;<\/div>\n<div class=\"timeline-item-right\">&nbsp;<\/div>\n<\/li>\n<li class=\"timeline-item\">\n<div class=\"timeline-item-content\"><label>2020\/07–2022\/07<\/label>\n<div>中国博士后科学基金第68批面上资助二等，已结题、项目负责人。<\/div>\n<\/div>\n<div class=\"timeline-item-tail\">&nbsp;<\/div>\n<div class=\"timeline-item-head\">&nbsp;<\/div>\n<div class=\"timeline-item-right\">&nbsp;<\/div>\n<\/li>","ryhj":"<div>1. 第五届世界诊疗大会旅行奖&nbsp;&nbsp;<\/div>\n<div>2. 博士研究生国家奖学金<\/div>\n<div>3. 高水平期刊论文奖<\/div>\n4. 山东省优秀毕业生&nbsp;","xpwj":"http://sourcedb.simm.cas.cn/zw/gb2020/yjzz/202207/P020220715369860630534.jpg","kycg":"<div>迄今已发表SCI论文30余篇，其中以共同通讯或第一（含共一）作者在<i><font face=\"Arial\">J. Am. Chem. Soc., Chem. Sci., Theranostics, Sci. Bull., Chem. Soc. Rev., Coord. Chem. Rev<\/font><\/i>.等国内外知名期刊发表论文19篇，总引用&gt; 1400，h指数15。<\/div>\n&nbsp;","shrz":"<div>1. 中国化学会会员<\/div>\n<div>2.《Frontier in Chemistry》期刊评审编辑（Review Editor）<\/div>\n<div>3. 英国皇家化学会国际期刊同行评议员。<\/div>","puburl":"http://sourcedb.simm.cas.cn/zw/gb2020/yjzz/202207/t20220715_6481308.json"});