cas_call({"xm":"徐宝福","xb":"男","zc":"研究员","xl":"博士","dh":"","cz":"","dzyj":"bfxu@simm.ac.cn","grzy":"","zjlb":"研究员","zw":"课题组长","txdz":"烟台市高新区滨海东路198号","grjj":"

徐宝福，中国科学院上海药物研究所研究员、博士生导师、课题组长。2018年12月博士毕业于中国科学院上海植物生理生态研究所，而后于2019年3月-2022年3月在美国佛罗里达大学化学系进行博士后研究，并于2022年6月加入中国科学院上海药物研究所新建研究组任课题组长。<\/p>\n

 <\/p>\n

主要从事天然产物生物合成的研究，涉及基因组挖掘、合成途径解析、酶催化机制解析以及活性天然产物的量产等。已在国际学术期刊上发表过11篇SCI文章，其中第一作者（含共同）7篇，包括Angew. Chem. Int. Ed.、ACS Catal.、Org. Lett.、Phytochemistry、Chem. Sci.、Nat. Prod. Rep.<\/em><\/font> 等。<\/p>\n

 <\/p>\n

教育经历：<\/strong><\/p>\n

1.2013.09 - 2018.12，中国科学院上海植物生理生态研究所，微生物学，博士<\/p>\n

2. 2009.09 - 2013.07，山东农业大学，生物工程，学士<\/p>","yjfx":"

1.基因组分析导向的活性天然产物挖掘与鉴定<\/p>\n

2.天然产物生物合成途径解析<\/p>\n

3.酶催化机制及应用<\/p>\n

4.体外\/体内合成生物学量产活性天然产物<\/p>","dblz":"

1.Baofu Xu<\/strong>, Dean J. Tantillo, Jeffrey D. Rudolf; Mechanistic Insights into the Formation of the 6,10-Bicyclic Eunicellane Skeleton by the Bacterial Diterpene Synthase Bnd4, Angewandte Chemie International Edition<\/em>, 2021, 60(43): 23159-23163.<\/font><\/p>\n

2.Chenxi Zhu#, Baofu Xu<\/strong>#, Donovon A. Adpressa, Jeffrey D. Rudolf; Sandra Loesgen; Discovery and Biosynthesis of a Structurally Dynamic Antibacterial Diterpenoid, Angewandte Chemie International Edition<\/em>, 2021, 60(25): 14163-14170. (共一)<\/font><\/p>\n

3.Baofu Xu<\/strong>, Zining Li, Tyler A. Alsup, Michelle A. Ehrenberger, Jeffrey D. Rudolf; Bacterial Diterpene Synthases Prenylate Small Molecules, ACS Catalysis<\/em>, 2021, 11(10): 5906-5915.<\/font><\/p>\n

4.Baofu Xu<\/strong>, Zhen Fan, Yongxing Lei, Yu Ping, Amit Jaisi, Youli Xiao; Insights into Pipecolic Acid Biosynthesis in Huperzia serrata, Organic Letters<\/em>, 2018, 20(8): 2195-2198.<\/font><\/p>\n

5.Baofu Xu<\/strong>, Lei Lei, Xiaocen Zhu, Yiqing Zhou, Youli Xiao; Identification and characterization of L-lysine decarboxylase from Huperzia serrata and its role in the metabolic pathway of lycopodium alkaloid, Phytochemistry<\/em>, 2017, 136: 23-30.<\/font><\/p>\n

6.Bao Chen#, Peiju Qiu#, Baofu Xu<\/strong>#, Qingmin Zhao, Yu-Cheng Gu, Lei Fu, Shijie Bi, Lefu Lan, Chang-Yun Wang, and Yue-Wei Guo; Cytotoxic and Antibacterial Isomalabaricane Terpenoids from the Sponge Rhabdastrella globostellata, Journal of Natural Products<\/em>, 2022. (共一)<\/font><\/p>\n

7.Baofu Xu<\/strong>; Wenbo Ning; Xiuting Wei; Jeffrey Rudolf; Mutation of the eunicellane synthase Bnd4 alters its product profile and expands its prenylation ability. ChemRxiv<\/em>. Cambridge: Cambridge Open Engage; 2022; (Preprint)<\/font><\/p>\n

8.Jeffrey D. Rudolf, Tyler A. Alsup, Baofu Xu<\/strong>, Zining Li; Bacterial terpenome, Natural Products Reports<\/em>, 2020, 38: 905-980.<\/font><\/p>\n

9.Yu Ping, Xiaodong Li, Baofu Xu<\/strong>, Wei Wei, Wenping Wei, Guoyin Kai, Zhihua Zhou, Youli Xiao; Building Microbial Hosts for Heterologous Production of N-Methylpyrrolinium, ACS Synthetic Biology<\/em>, 2019, 8(2): 257-263.<\/font><\/p>\n

10.Mengquan Yang, Wenjing You, Shiwen Wu, Zhen Fan, Baofu Xu<\/strong>, Mulan Zhu, Xuan Li, Youli Xiao; Global transcriptome analysis of Huperzia serrata and identification of critical genes involved in the biosynthesis of huperzine A, BMC Genomics,<\/em> 2017, 18(1): 1-11.<\/font><\/p>\n

11.Nisha He, Pan Wu, Yongxing Lei, Baofu Xu<\/strong>, Xiaochen Zhu, Gudan Xu, Yaojie Gao, Jianzhao Qi, Zixin Deng, Gongli Tang, Wenqing Chen, Youli Xiao; Construction of an octosyl acid backbone catalyzed by a radical S-adenosylmethionine enzyme and a phosphatase in the biosynthesis of high-carbon sugar nucleoside antibiotics, Chemical Science<\/em>, 2016, 8: 444-451.<\/font><\/p>","jyjl":"","gzjl":"

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