cas_call({"xm":"李翼","xb":"男","zc":"研究员","xl":"博士","dh":"0760-85286866","cz":"","dzyj":"liyi@simm.ac.cn","grzy":"","zjlb":"研究员","zw":"课题组长","txdz":"广东翠亨新区中瑞（欧）工业园健康医药示范区","grjj":"<div>李翼，研究员，课题组长。2009年毕业于武汉大学，获理学学士学位；2014年毕业于中国科学院上海药物研究所，获理学博士学位，同年留所工作，任博士后研究员。2016年，入选上海药明康德“青年人才计划”，在国内新药研发部从事小分子创新药物研发，期间作为项目药化负责人，负责多个新药项目从立项、临床前研究、开发到临床申报（IND）工作。2018年赴美，在美国德克萨斯大学医学分部从事博士后研究；2022年6月起加入中国科学院上海药物研究所、中科中山药物创新研究院，担任研究员、课题组长。<\/div>\n<div>&nbsp;<\/div>\n<div>迄今为止，作为项目药化负责人和专利主要发明人，已成功推进4个候选新药完成了系统临床前研发和临床试验申报；<i>在<font face=\"Arial\">J. Med. Chem., ACS Catal. Org. Lett., Chem. Comm.<\/font><\/i>等国际权威药物化学和有机化学学术期刊上发表学术论文共24篇（第一和共同第一作者13篇），累计总影响因子大于140，总他引次数超过450次；申请或授权发明专利15项（13项为PCT专利）；撰写英文专著2章。多个研究成果发表后受到国际同行的关注和好评，其中6篇被德国化学评论期刊Synfacts作为亮点报道， 4篇被选为期刊封面文章，1篇被ChemComm推荐为Editor’s Choice，1篇被选为<i><font face=\"Arial\">ACS Catal<\/font>.<\/i>期刊首页推荐文章。获中国科学院院长优秀奖，赛诺菲-中科院上海生命科学院优秀博士后奖等荣誉。<\/div>\n<div><span style=\"font-size: 12pt;\">　<\/span><\/div>\n<div>2009.09-2014.06，中国科学院上海药物研究所，药物化学，博士<\/div>\n<div>2005.09-2009.06，武汉大学药学院，药学，本科&nbsp;<\/div>\n&nbsp;","yjfx":"<div>抗肿瘤和代谢性疾病的创新药物研发；<\/div>\n<div>基于药物优势骨架的有机合成新方法研究<\/div>\n&nbsp;","dblz":"<div><font face=\"Arial\" style=\"line-height: 150%;\">1.Z. Liu#, <b>Y. Li#<\/b>, H. Chen, H.-T. Lai, P. Wang, S.-Y. Wu, E. A. Wold, P. G. Leonard, S. Joseph, H. Hu, C.-M. Chiang, A. R. Brasier*, B. Tian*, J. Zhou*, Discovery, X-ray Crystallography, and Anti-Inflammatory Activity of Bromodomain-Containing Protein 4 (BRD4) Inhibitors Targeting a Distinct New Binding Site, <i>J. Med. Chem<\/i>. 2022, 65, 2388-2408. (Cover Article and Selected as the Special Issue “Epigenetics 2022”)<\/font><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\">2.<b>Y. Li#<\/b>, J. Chen#, A. Bolinger, H. Chen, Z. Liu, Y. Cong, A. R. Brasier, I. V. Pinchuk, B. Tian*, J. Zhou*, Target-Based Small Molecule Drug Discovery towards Novel Therapeutics for Inflammatory Bowel Diseases, <i>Inflamm. Bowel Dis<\/i>. 2021, 27, S38–S62.<\/font><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\">3.<b>Y. Li<\/b>, M. Xu*, Applications of Asymmetric Petasis Reaction in the Synthesis of Chiral Amines, <i>Acta Chim. Sinica<\/i> 2021, 79, 1345.<\/font><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\">4.<b>Y. Li#<\/b>, Z. Liu#, G. Aglyamova#, J. Chen, H. Chen, M. Bhandari, M. A. White, G. Rudenko？, J. Zhou？, Discovery of Phenanthridine Analogues as Novel Chemical Probes Disrupting the Binding of DNA to ΔFosB Homodimers and ΔFosB\/JunD Heterodimers, <i>Bioorg. Med. Chem. Lett.<\/i> 2020, 30, 127300.<\/font><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\">5.<b>Y. Li#<\/b>, B. Liu#, M. Xu*, Rhodium-Catalyzed Enantioselective Alkenylation of Cyclic Ketimines: Synthesis of Multifunctional Chiral α,α-Disubstituted Allylic Amine Derivatives, <i>Org. Lett<\/i>. 2018, 20, 2306. (Highlighted by Synfacts, 2018, 14, 0596)<\/font><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\">6.<b>Y. Li#<\/b>, Y. Yu#, M. Xu*, Simple Open-Chain Phosphite-Olefin as Ligand for Rh-Catalyzed Asymmetric Arylation of Cyclic Ketimines: Enantioselective Access to gem-Diaryl α-Amino Acid Derivatives, <i>ACS Catal.<\/i> 2016, 6, 661. (Highlighted by The Journal Homepage).<\/font><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\">7.H. Wang#, <b>Y. Li#<\/b>, M. Xu*, Rhodium-Catalyzed Highly Enantioselective Arylation of Cyclic Diketimines: Efficient Synthesis of Chiral Tetrasubstituted 1,2,5-Thiadiazoline 1,1-Dioxides, <i>Org. Lett.<\/i> 2014, 16, 3962. (Highlighted by Synfacts, 2014, 10, 1044)&nbsp;<\/font><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\">8.<b>Y. Li<\/b>, M. Xu*, Rhodium-Catalyzed Asymmetric Tandem Cyclization for Efficient and Rapid Access to Underexplored Heterocyclic Tertiary Allylic Alcohols Containing a Tetrasubstituted Olefin, <i>Org. Lett<\/i>. 2014, 16, 2712. (Highlighted by Synfacts, 2014, 10, 0680)&nbsp;<\/font><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\">9.<b>Y. Li<\/b>, M. Xu*, Simple Sulfur-Olefins as New Promising Chiral Ligands for Asymmetric Catalysis,<i> Chem. Commun<\/i>. 2014, 50, 3771. (Feature Article, Selected as Cover Article)&nbsp;<\/font><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\">10.<b>Y. Li<\/b>, D. Zhu, M. Xu*, A new Versatile Approach to Enantioenriched 3-Hydroxyoxindoles, 1, 3-Dihydroisobenzofuran and 3-Isochromanone Derivatives by Rhodium-Catalyzed Asymmetric Arylation\/Cyclization Sequence, <i>Chem. Commun<\/i>. 2013. 49, 11659. (Highlighted by Synfacts, 2014, 10, 0285; ChemComm Editor’s Choice)&nbsp;<\/font><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\">11.<b>Y. Li<\/b>, M. Xu*, Lewis Acid-Catalyzed Intramolecular Aza-Friedel-Crafts Reaction of N-tert-Butanesulfinyl Imines: Efficient Synthesis of Optically Active 9-Aminoflourene Derivatives, <i>Asian J. Org. Chem<\/i>. 2013, 2, 50-53. (Selected as Cover Article; One of the most-accessed Asian J. Org. Chem. articles in April 2013)&nbsp;<\/font><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\">12.<b>Y. Li<\/b>, M. Xu*, Lewis Acid-Promoted Highly Diastereoselective Petasis Borono-Mannich Reaction: Efficient Synthesis of Optically Active β, γ-Unsaturated α-Amino Acids,<i> Org. Lett.<\/i> 2012, 14, 2062. (Highlighted by Synfacts, 2012, 8, 0744)&nbsp;<\/font><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\">13.<b>Y. Li<\/b>, D. Ji, M. Xu*, Highly Diastereoselective Friedel-Crafts Reaction of Arenes with N-tert-Butanesulfinylimino Ester towards the Efficient Synthesis of α-Arylglycines, <i>Org. Biomol. Chem.<\/i> 2011, 9, 8452.<\/font><\/div>\n<div><font face=\"Arial\" style=\"line-height: 150%;\"><br style=\"line-height: 150%;\" \/>\n<\/font><\/div>\n<font face=\"Arial\" style=\"line-height: 150%;\">&nbsp;<\/font>","jyjl":"","gzjl":"<li class=\"timeline-item\">\n<div class=\"timeline-item-content\"><label>2022.06-至今<\/label>\n<div>中国科学院上海药物研究所\/中科中山药物创新研究院，研究员、课题组长<\/div>\n<\/div>\n<div class=\"timeline-item-tail\">&nbsp;<\/div>\n<div class=\"timeline-item-head\">&nbsp;<\/div>\n<div class=\"timeline-item-right\">&nbsp;<\/div>\n<\/li>\n<li class=\"timeline-item\">\n<div class=\"timeline-item-content\"><label>2018.12-2022.04<\/label>\n<div>美国德克萨斯大学医学分部，博士后<\/div>\n<\/div>\n<div class=\"timeline-item-tail\">&nbsp;<\/div>\n<div class=\"timeline-item-head\">&nbsp;<\/div>\n<div class=\"timeline-item-right\">&nbsp;<\/div>\n<\/li>\n<li class=\"timeline-item\">\n<div class=\"timeline-item-content\"><label>2016.08-2018.11<\/label>\n<div>上海药明康德新药研发有限公司，国内新药研发部，管理培训生\/项目主管<\/div>\n<\/div>\n<div class=\"timeline-item-tail\">&nbsp;<\/div>\n<div class=\"timeline-item-head\">&nbsp;<\/div>\n<div class=\"timeline-item-right\">&nbsp;<\/div>\n<\/li>\n<li class=\"timeline-item\">\n<div class=\"timeline-item-content\"><label>2014.07-2016.07<\/label>\n<div>中国科学院上海药物研究所，博士后<\/div>\n<\/div>\n<div class=\"timeline-item-tail\">&nbsp;<\/div>\n<div class=\"timeline-item-head\">&nbsp;<\/div>\n<div class=\"timeline-item-right\">&nbsp;<\/div>\n<\/li>","ktxm":"","ryhj":"<div>2017年，药明康德年度杰出员工奖&nbsp;<\/div>\n<div>2015年，赛诺菲-中国科学院上海生命科学研究院优秀博士后奖&nbsp;<\/div>\n<div>2014年，中国科学院“院长奖”优秀奖<\/div>\n<div>2014年，中国科学院“三好学生标兵”<\/div>\n<div>2013年，博士生国家奖学金<\/div>\n<div>2012年，中国科学院“优秀学生干部”<\/div>\n<div>2009年，武汉大学优秀毕业生<\/div>\n<div>2007年，本科生国家奖学金<\/div>\n2007年，武汉大学优秀学生干部&nbsp;","xpwj":"http://sourcedb.simm.cas.cn/zw/gb2020/yjzz/202206/P020220621596421091775.jpg","kycg":"<div>1.作为项目药化负责人和专利主要发明人，成功推进多个候选化合物完成了系统临床前研究和临床试验申报，其中2个已获国家药品监督管理局临床试验默示许可，1个已完成pre-IND申请递交，1个已完成全面临床前评估，涉及治疗领域包括抗肿瘤，以及糖尿病和肥胖等代谢性疾病；<\/div>\n<div>&nbsp;<\/div>\n<div>2.首次发现了靶向BRD4的全新变构位点，而非经典的乙酰化赖氨酸（KAc）结合口袋的BRD4 BD1选择性变构抑制剂，并证明了其作用机制和用于治疗炎症性疾病的潜力。这一全新别构位点及其抑制剂的发现不仅为新型BRD4选择性小分子别构调节剂的设计和研发提供了新的方向，而且对研究BRD4相关的表观遗传系统和蛋白-蛋白相互作用的生物学功能具有重大意义；<\/div>\n<div>&nbsp;<\/div>\n<div>3.发展了一系列构建高光学纯度手性胺、非天然α-氨基酸，以及含季碳手性的特殊杂环类化合物的不对称合成方法学。这些方法相比文献已有报道，立体选择性高、底物适用范围广，为今后相关手性药物的设计合成提供了重要的方法学支持。目前，部分方法已被成功用于默克公司报道的 BACE-1 抑制剂(R)-iminohydantoin的首次催化不对称合成中。<\/div>\n&nbsp;","shrz":"","puburl":"http://sourcedb.simm.cas.cn/zw/gb2020/yjzz/202206/t20220621_6464346.json"});