cas_call({"xm":"罗成","xb":"男","zc":"研究员","xl":"博士","dh":"86-21-68077947","cz":"021-50807188","dzyj":"cluo@simm.ac.cn","grzy":"","zjlb":"研究员;杰青","zw":"课题组长","txdz":"上海市祖冲之路555号","grjj":"
罗成,中科院上海药物所研究员,博士生导师,2016年获国家杰出青年基金资助,上海市优秀学科带头人。研究领域:药物设计和化学生物学。罗成发展多学科交叉技术,针对重大疾病相关通路\/靶标,开展基于药物化学生物学的靶标新功能发现、药物作用机理研究和创新药物研发。发现了多个重要天然产物或内源代谢物的作用靶标,揭示了多个重要药物靶标的调控机制;发现包括铜转运蛋白抑制剂DC-AC50、难靶蛋白RhoA抑制剂DC-Rhoin、LC3抑制剂DC-LC3in-D5等一批具有开发前景的先导化合物,三个化合物进入了临床前评价。研究结果在Nature、Cancer Cell、Nature Chem、Nature Comm、JACS、PNAS、Nucleic Acid Res和J Med Chem<\/i>等国际著名杂志发表SCI论文>200篇,总影响因子(IF)约1600,H因子44,论著被引用>8400余次。申请专利56项(美国专利1项、PCT 10项),获得授权专利5项(五项成果已经完成转化);主持“863”课题、基金委重点项目、杰青等项目10余项。已经培养研究生50余名,部分研究生在哈佛大学、麻省理工、斯坦福大学、芝加哥大学和宾夕法尼亚大学等世界著名高校从事博士后研究,部分已经在德国海德堡大学、中科院等国内外高校获独立PI工作。<\/p>\n <\/p>\n 教育经历:<\/strong><\/p>\n 9\/2001-7\/2004 中国科学院上海药物研究所有机化学 博士<\/p>\n 9\/1998-7\/2001 复旦大学化学系物理化学 硕士<\/p>\n 9\/1990-7\/1994 福州大学化学系化学(结构化学) 学士<\/p>","yjfx":"主要研究方向为药物设计和药物化学生物学。运用包括靶标发现、计算机辅助药物设计、分子动力学模拟、生物信息学等理论模拟方法为指导,结合包括生物化学、结构生物学和药物化学生物学等多学科交叉手段,开展包括表观遗传修饰酶和重要蛋白-蛋白相互作用的新靶标、新机制的创新药物及其作用机理研究。","dblz":" 1.Lulu Hu#, Junyan Lu#, Jingdong Cheng#, Qinhui Rao, Ze Li, Haifeng Hou, Zhiyong Lou, Lei Zhang, Wei Li, Wei Gong, Mengjie Liu, Chang Sun, Xiaotong Yin, Jie Li, Xiangshi Tan, Pengcheng Wang, Yinsheng Wang, Dong Fang, Qiang Cui, Pengyuan Yang, Chuan He, Hualiang Jiang, Cheng Luo* and Yanhui Xu*, Structural Insight into Substrate Preference for TET-mediated Oxidation. Nature 2015;527(7576):118-22.<\/p>\n 2.Jing Wang#, Cheng Luo#(共同第一), Changliang Shan#, Qiancheng You#, Junyan Lu Shannon Elf, Yu Zhou, Yi Wen, Yuxin Xie, Jan L Vinkenborg, Jun Fan, Heebum Kang, Dali Han, Jason Karpus, Shijie Chen, Shisheng Ouyang, Chihao Luan, Naixia Zhang, Maarten Merkx, Hong Liu, Jing Chen*, Hualiang Jiang*, Chuan He*, Inhibition of human copper trafficking significantly attenuates tumor growth. Nature Chem 2015; 7(12):968-79.<\/p>\n 3.Junyan Lu, Chenxiao Jianga, Xiaojing Lia, Lizhi Jiang, Zengxia Li, Tilman Schneider-Poetsch, Kunqian Yu, Jun O. Liu, Hualiang Jiang, Cheng Luo*, Yongjun Dang*. The Inter-domain Linker of eIF4AI Regulates ATP Hydrolysis Coupled Duplex Unwinding, Nucleic Acids Res 2015;. pii: gkv1033.<\/p>\n 4.Fanwang Meng, Sufang Cheng, Hong Ding, Shien Liu, Ying Liu, Kongkai Zhu, Shijie Chen, Junyan Lu, Yiqian Xie, Linjuan Li, Rongfeng Liu, Zhe Shi, Yu Zhou, Yu-Chih Liu, Mingyue Zheng, Hualiang Jiang, Wencong Lu*, Hong Liu*, and Cheng Luo*. Discovery and optimization of novel, selective histone methyltransferase SET7 inhibitors by pharmacophore- and docking-based virtual screening. J Med Chem, 2015; 58(20):8166-81.<\/p>\n 5.Xiangqian Kong, Jian Liu, Lianchun Li, Liyan Yue, Lihong Zhang, Hualiang Jiang, Xin Xie*, Cheng Luo*, Functional Interplay Between the RK motif and Linker Segment Dictates Oct4-DNA Recognition, Nucleic Acids Res 2015;43(9):4381-92.<\/p>\n 6.Yue Huang, Jingli Yan, Qi Li, Jiafei Li, Shouzhe Gong, Hu Zhou, Jianhua Gan, Hualiang Jiang, Gui-Fang Jia*, Cheng Luo*, and Cai-Guang Yang* Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acid Res 2015; 43(1):373-84.<\/p>\n 7.Xiangqian Kong, Limin Chen, Lianying Jiao, Xiangrui Jiang, Fulin Lian, Junyan Lu, Kongkai Zhu, Daohai Du, Jingqiu Liu, Hong Ding, Naixia Zhang, Jingshan Shen, Mingyue Zheng, Kaixian Chen, Xin Liu, Hualiang Jiang and Cheng Luo*. Astemizole Arrests the Proliferation of Cancer Cells by Disrupting the EZH2-EED Interaction of Polycomb Repressive Complex 2. J Med Chem, 2014; 57:9512-21.<\/p>\n 8.Shijie Chen, Yulan Wang, Wen Zhou, Shanshan Li, Jianlong Peng, Zhe Shi, Junchi Hu, Yu-Chih Liu, Hong Ding, Yijyun Lin, Linjuan Li, Sufang Cheng, Jingqiu Liu, Tao Lu, Hualiang Jiang, Bo Liu*, Mingyue Zheng* and Cheng Luo*. Identifying Novel Selective Non-Nucleoside DNA Methyltransferase 1 Inhibitors through Docking-Based Virtual Screening. J Med Chem, 2014;57,9028-41.<\/p>\n 9.Jie Zhang, Hongchuan Liu, Kongkai Zhu, Shouzhe Gong, Shaynoor Dramsi, Ya-Ting Wang, Jiafei Li, Feifei Chen, Ruihan Zhang, Lu Zhou, Lefu Lan, Hualiang Jiang, Olaf Schneewind*, Cheng Luo*, Cai-Guang Yang*. Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase. P Natl Acad Sci 2014;111(37):13517-22.<\/p>\n 10.Yifan Jiang, Junyan Lu, Yaping Wang, Feng Zeng, Huiyuan Wang, Huige Peng, Min Huang, Hualiang Jiang, Cheng Luo* and Yongzhuo Huang*. Molecular Dynamic Simulation-driven Design of Protease-responsive Probe for in vivo Tumor Imaging. Adv Mater 2014;26(48):8174-8.<\/p>","jyjl":"