中国科学院上海药物研究所，药物化学研究室，副研究员，硕士生导师 

　　教育经历： 

　　2005/09-2010/06，华东理工大学，制药工程与技术专业   工学博士（2006/03-2010/03，上海药物研究所李援朝研究员课题组联合培养） 

　　2001/09-2005/06，西南大学，学士 

　　工作经历： 

　　2012/11 – 至今，中国科学院上海药物研究所，副研究员 

　　2012/07 – 2012/10，中国科学院上海药物研究所，助理研究员 

　　2010/06 – 2012/06，中国科学院上海药物研究所，博士后 

　　1. 基于天然产物自身活性特点，对其活性单体进行修饰改造、构效关系研究及新药开发。代表性工作：雷公藤内酯醇构效关系研究及抗肿瘤新药开发。 

　　2. 从事表观遗传修饰相关研究，基于靶点进行小分子抑制剂的设计合成。所涉及的靶点：menin-MLL，Bromodomain，EZH2，DOT1L等。 

　　3. 开展金属催化的C-H活化方法学研究，高效构建活性小分子及天然产物骨架。 

　　1. 自2009年起，共计发表论文34篇，含第一作者及通讯作者17篇，他引频次：828次，h-index：18（数据来源web of science），申请国内专利 > 10项。 

　　2. 2012年上海药学科技奖（二等奖，第三完成人）一类新药“雷腾舒”（LLDT-8）的重要原料雷酚内酯甲醚的合成与雷公藤内酯二醇首次全合成。 

　　3. 2015年上海药物所“新星计划”。 

一作文章（含共同^†） 

1. Yaxi Yang, Xuan Wang, Yuanchao Li, and Bing Zhou^*, A [4+1] Cyclative Capture Approach to 3H-Indole-N-oxides at Room Temperature by Rhodium(III)-Catalyzed C-H Activation, Angew. Chem. Int. Ed., 2015, 54, 15400 -15404. 

2. Yaxi Yang, Wei Hou, Lihuai Qin, Juanjuan Du, Huijin Feng, Bing Zhou^*, Yuanchao Li^*, Rhodium-Catalyzed Directed Sulfenylation of Arene C–H Bonds, Chem. European J., 2014, 20, 416-420.  

3. Yaxi Yang, Longtai Zheng, Jingjing Shi, Bo Gao, Yanke Chen, Huichi Yang, Hongli Chen^*, Yuanchao Li^*, Xuechu Zhen^*, Synthesis of 5 alpha-cholestan-6-one derivatives and their inhibitory activities of NO production in activated microglia: Discovery of a novel neuroinflammation inhibitor, Bioorg. Med. Chem. Lett., 2014, 24, 1222-1227.  

4. Bing Zhou^†*, Yaxi Yang^†, Sui Lin and Yuanchao Li^*, Rhodium-Catalyzed Direct Addition of Indoles to N-Sulfonylaldimines, Adv. Synth. Catal., 2013, 355, 360-364.  

5. Yaxi Yang, Bing Zhou^* and Yuanchao Li^*, Rhodium-Catalyzed Oxidative ortho-Acylation of Aryl Ketone O-Methyl Oximes with Aryl and Alkyl Aldehydes, Adv. Synth. Catal., 2012, 354, 2916-2920.  

6. Bing Zhou^†, Yaxi Yang^†, Yuanchao Li^*, Rhodium-catalyzed oxidative C2-acylation of indoles with aryl and alkyl aldehydes, Chem. Commun., 2012, 48, 5163-5165.  

7. Zhaoli Zhou^†, Yaxi Yang^†, Jian Ding, Yuanchao Li^*, Zenghong, Miao, Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms, Nat. Prod. Rep., 2012, 29, 457-475.  

8. Yaxi Yang, Zheng Li, Huijin Feng, Guorong Chen, Yuanchao Li^*, Concise synthesis of five-membered ring carbasugars based on key ring-closing metathesis, Tetrahedron Lett., 2010, 51, 3848-3851.  

通讯作者文章（含共同^*） 

1. Liyan Yue†, Juanjuan Du†, Fei Ye†, Zhifeng Chen, Lianchun Li, Xuan Wang, Fulin Lian, Wen Ai, Bidong Zhang, Naixia Zhang, Yuanyuan Zhang*, Hualiang Jiang, Kaixian Chen, Yuanchao Li, Yaxi Yang* and Cheng Luo*, Identification of novel small-molecule inhibitors targeting menin-MLL interaction, repurposing the antidiarrheals loperamide, Org. Biomol. Chem., 2016, 14, 8503-8519. 

2. Bing Zhou^*, Zhaoqiang Chen, Yaxi Yang^*, Wen Ai, Huanyu, Tang, Yunxiang Wu, Weiliang Zhu^*, Yuanchao Li, Redox-Neutral Rhodium-Catalyzed C-H Functionalization of Arylamine N-Oxides with Diazo Compounds: Primary C(sp³)-H/C(sp²)-H Activation and Oxygen-Atom Transfer, Angew. Chem., Int. Ed., 2015, 54, 12121-12126. 

3. Xuan Wang, Huanyu, Tang, Huijin Feng, Yuanchao Li^*, Yaxi Yang^*, Bing Zhou^*, Access to Six- and Seven-Membered 1,7-Fused Indolines via Rh(III)-Catalyzed Redox-Neutral C7-Selective C-H Functionalization of Indolines with Alkynes and Alkenes, J. Org. Chem., 2015, 80, 6238-6249.  

4. Wen Ai, Yunxiang Wu, Huanyu, Tang, Xueyan Yang^*, Yaxi Yang^*, Yuanchao Li, Bing Zhou^*, Rh(III)- or Ir(III)-catalyzed ynone synthesis from aldehydes via chelation-assisted C-H bond activation, Chem. Commun., 2015, 51, 7871-7874.  

5. Wen Ai, Xueyan Yang, Yunxiang Wu, Xuan Wang, Yuanchao Li, Yaxi Yang^*, Bing Zhou^*, Rhodium(III)- and Iridium(III)-Catalyzed C7 Alkylation of Indolines with Diazo Compounds, Chem. European J., 2014, 20, 17653-17657.  

6. Bing Zhou^*, Juanjuan Du, Yaxi Yang^*, Huijin Feng and Yuanchao Li, Rh(III)-Catalyzed C–H Amidation with N-Hydroxycarbamates: A New Entry to N-Carbamate-Protected Arylamines, Org. Lett., 2014, 16, 592-595.