1.Wang Y#, Di H#, Chen F, Xu Y, Xiao Q, Wang X, Wei H, Lu Y, Zhang L, Zhu J, Lan L*, Li J*. Discovery of Benzocycloalkane Derivatives Efficiently Blocking Bacterial Virulence for the Treatment of Methicillin-Resistant S. aureus (MRSA) Infections by Targeting Diapophytoene Desaturase (CrtN). J Med Chem. 2016 May 26;59(10):4831-48.
2.Wang Y#, Chen F#, Di H, Xu Y, Xiao Q, Wang X, Wei H, Lu Y, Zhang L, Zhu J, Sheng C, Lan L*, Li J*. Discovery of Potent Benzofuran-Derived Diapophytoene Desaturase (CrtN) Inhibitors with Enhanced Oral Bioavailability for the Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Infections. J Med Chem. 2016 Apr 14;59(7):3215-30. [ACS Editors' Choice? Articles; highlighted by BioCentury Innovations, 03/31/2016].
3.Chen F#, Di H#, Wang Y#, Cao Q, Xu B, Zhang X, Yang N, Liu G, Yang CG, Xu Y, Jiang H, Lian F, Zhang N, Li J*, Lan L*. Small-molecule targeting of a diapophytoene desaturase inhibits S. aureus virulence. Nat Chem Biol. 2016 Mar;12(3):174-9. [Highlighted by Nature Reviews Drug Discovery, (doi:10.1038/nrd.2016.35), Bioworld Today (01/20/2016), and BioCentury Innovations (01/28/2016)].
4.Yang N, Lan L*. Pseudomonas aeruginosa Lon and ClpXP proteases: roles in linking carbon catabolite repression system with quorum-sensing system. Curr Genet. 2016 Feb;62(1):1-6.
5.Yang N, Ding S, Chen F, Zhang X, Xia Y, Di H, Cao Q, Deng X, Wu M, Wong CC, Tian XX, Yang CG, Zhao J, Lan L*. The Crc protein participates in down-regulation of the Lon gene to promote rhamnolipid production and rhl quorum sensing in Pseudomonas aeruginosa. Mol Microbiol. 2015 May;96(3):526-47.
6.Ding Y, Liu X, Chen F, Di H, Xu B, Zhou L, Deng X, Wu M, Yang CG*, Lan L*. Metabolic sensor governing bacterial virulence in Staphylococcus aureus. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):E4981-90. [Highlighted by SciBX, 7(46); doi:10.1038/scibx.2014.1352]
7.Cao Q#, Wang Y#, Chen F, Xia Y, Lou J, Zhang X, Yang N, Sun X, Zhang Q, Zhuo C, Huang X, Deng X, Yang CG, Ye Y, Zhao J*, Wu M*, Lan L*. A novel signal transduction pathway that modulates rhl quorum sensing and bacterial virulence in Pseudomonas aeruginosa. PLoS Pathog. 2014 Aug 28;10(8):e1004340.
8.Deng X#, Liang H#, Chen K, He C, Lan L*, Tang X*. Molecular mechanisms of two-component system RhpRS regulating type III secretion system in Pseudomonas syringae. Nucleic Acids Res. 2014 Oct;42(18):11472-86.
9.陈菲菲, 狄红霞, 蓝乐夫*. 金黄色葡萄球菌重要毒力因子的功能及其抑制剂研究进展,科学通报,2013, 58: 3743-3752.
10.Liu X, Sun X, Wu Y, Xie C, Zhang W, Wang D, Chen X, Qu D, Gan J, Chen H, Jiang H, Lan L*, Yang CG*. Oxidation-sensing regulator AbfR regulates oxidative stress responses, bacterial aggregation, and biofilm formation in Staphylococcus epidermidis. J Biol Chem. 2013 Feb 8;288(6):3739-52.
11.Sun F, Ding Y, Ji Q, Liang Z, Deng X, Wong CC, Yi C, Zhang L, Xie S, Alvarez S, Hicks LM, Luo C, Jiang H, Lan L*, He C*. Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15461-6. Highlighted by Sci. Signal. DOI: 10.1126/scisignal.2003635)